Browsing by Subject "Transfection"
Now showing items 1-5 of 5
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Characterisation of the differentially regulated trout protein 1 (DRTP1) gene in rainbow trout (Oncorhynchus mykiss)
(Elsevier, 2008-10-04)Increased levels of differentially regulated trout protein 1 (DRTP1) mRNA transcripts have been reported in fish after activation of the acute phase response. While the function of the DRTP1 protein still remains to be ... -
Design and development of polymeric transfection vectors for gene delivery in Recessive Dystrophic Epidermolysis Bullosa
(2014-07-23)Recessive Dystrophic Epidermolysis Bullosa (RDEB) is caused by mutations in the collagen VII gene (COL7A1) that lead to an alteration of function or a reduction in the amounts of collagen VII protein (C7). Any of these ... -
Developing reservoir systems for therapeutic delivery of biomolecules to a degenerated disc
(2015-01-05)Low back pain has severe consequences for the quality of life of the affected patients and strong evidence suggests that this condition is caused by degeneration of the intervertebral disc (IVD). Disc degeneration coincides ... -
A reliable method for detecting complexed DNA in vitro
(The Royal Society of Chemistry, 2010-09-08)Quantification of eluted nucleic acids is a critical parameter in characterizing biomaterial based gene-delivery systems. The most commonly used method is to assay samples with an intercalating fluorescent dye such as ... -
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
(American Chemical Society, 2012-02-12)The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ...