Browsing by Author "Rochev, Yury"
Now showing items 1-14 of 14
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Development of Simplified NIPAm-based Thermoresponsive Films for Cell Preservation, Expansion and Differentiation
Fan, Xingliang (2013-12-16)Traditional cell recovery methodologies cleave cell-to-cell junctions and thus the recovery of an intact cell sheet for use in tissue engineering is rendered impossible. Additionally, these traditional cell detachment ... -
Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells
Prasad, Babu R.; Mullins, Gillian; Nikolskaya, Natalia; Connolly, David; Smith, Terry; Rochev, Yury (BioMed Central, 2012-01-20)Background: The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid ... -
Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance
Shirazi, Reyhaneh Neghabat; Aldabbagh, Fawaz; Ronan, William; Erxleben, Andrea; Rochev, Yury; McHugh, Peter (Springer Verlag, 2016-09-02)In this study, the effects of material thickness and processing method on the degradation rate and the changes in the mechanical properties of poly(lactic-co-glycolic acid) material during simulated physiological degradation ... -
Experimental and computational analysis of the mechanical behavior of poly(lactic-co-glycolic acid) during degradation for medical implant applications
Neghabat Shirazi, Reyhaneh (2016-01-25)Biodegradable polymers such as PLGA have been used in a wide range of biomedical applications due to their hydrolytic degradation and biocompatibility. The mechanical performance of biodegradable polymers during degradation ... -
Global gene expression analysis of the effects of Vinblastine on endothelial cells, when eluted from a thermo-responsive polymer
McLucas, Emily; Rochev, Yury; Carroll, W. M.; Smith, Terry (Wiley Online Library, 2006-06-30)In-stent restenosis remains a significant problem associated with bare metal stents. This drawback has prompted research into improving stent design and the development of novel coatings, including drug-eluting stents. A ... -
In-vitro cellular interaction of quantum dots and silicone surfaces
Bodi, Babu Rajendra Prasad (2011-09-30)The main hypothesis on which this study has been based is that the surface modification of nano-particles of different size (Quantum Dots) and varying nano-surfaces roughness (Silicones of nanosurface roughness) can make ... -
Integrating the old and new: smart thermoresponsive surfaces and 3D fabrication technologies for tissue engineering
Dzhoyashvili, Nina (2017-05-08)One promising direction of regenerative medicine is the development of cell sheet-based tissue-like constructs. The cell sheets preserve ECM and cell−cell junctions. This may greatly support cell adherence to damaged organ ... -
Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use
Prasad, Babu R.; Nikolskaya, Natalia; Connolly, David; Smith, Terry; Rochev, Yury (2010)Background: The unique and tuneable photonic properties of Quantum Dots (QDs) have made them potentially useful tools for imaging biological entities. However, QDs though attractive diagnostic and therapeutic tools, have ... -
Macromolecularly crowded in vitro microenvironments accelerate the production of extracellular matrix-rich supramolecular assemblies.
Kumar, Pramod; Satyam, Abhigyan; Fan, Xingliang; Collin, Estelle; Rochev, Yury; Joshi, Lokesh; Pandit, Abhay; Zeugolis, Dimitrios I. (Nature Publishing Group, 2015-03-04)Therapeutic strategies based on the principles of tissue engineering by self-assembly put forward the notion that functional regeneration can be achieved by utilising the inherent capacity of cells to create highly ... -
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
Shirazi, Reyhaneh Neghabat; Ronan, William; Rochev, Yury; McHugh, Peter (Elsevier, 2015-09-02)Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ... -
Molecular Beacons for Tissue Engineering Applications
Alexander, Jennifer (2012-09-28)A complete spatiotemporal profile of the mechanisms involved in the synthesis, processing, and transport of RNA will improve our understanding of cell function and behaviour under various biological cues, which could ... -
Quantum dots in bio-imaging and drug delivery
Gladkovskaya, Olga (2015-11-23)This work explores a range of bionanomaterials, with particular attention to their influence on cell growth, function and fate. Also the issue of intracellular nanoparticles quantification has been addressed in experimental ... -
Smart biomaterials for cell sheet engineering
Healy, Deirdre (2016-03-23)The aim of this instigation was to develop thermoresponsive polymer films for cell culture use. Conventional cell detachment methods involve the use of proteolytic enzymes, such as trypsin, or mechanical scrapping. These ... -
Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro
McMahon, Siobhan; Nikolskaya, Natalia; Ní Choileain, Siobhan; Hennessy, Niamh; O'Brien, Timothy; Rochev, Yury (Wiley, 2011-11-01)Background The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried ...