Browsing by Author "Pakos-Zebrucka, Karolina"

Now showing items 1-4 of 4

    • Cellular response to stress: role of autophagy and cell death in caspase-9 deficient cells 

      Pakos-Zebrucka, Karolina (2017-10-31)
      Chronic or unresolved stress can lead to cell death, and induction of apoptosis is crucial when the cellular adaptive mechanisms are not able to resolve persistent stress. Malfunction of the apoptotic process caused by ...

    • Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under er stress conditions 

      Deegan, Shane; Saveljeva, Svetlana; Logue, Susan E; Pakos-Zebrucka, Karolina; Gupta, Sanjeev; Vandenabeele, Peter; Bertrand, Mathieu JM; Samali, Afshin (Informa UK Limited, 2014-11-02)
      Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and ...

    • Endoplasmic reticulum stress-mediated induction of sestrin 2 potentiates cell survival 

      Saveljeva, Svetlana; Cleary, Patricia; Mnich, Katarzyna; Ayo, Abiodun; Pakos-Zebrucka, Karolina; Patterson, John B.; Logue, Susan E.; Samali, Afshin (Impact Journals, LLC, 2016-02-22)
      Upregulation of SESTRIN 2 (SESN2) has been reported in response to diverse cellular stresses. In this study we demonstrate SESTRIN 2 induction following endoplasmic reticulum (ER) stress. ER stress-induced increases in ...

    • The integrated stress response 

      Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO Press, 2016-09-14)
      In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ...