Browsing by Subject "Olfactory bulbectomy"
Now showing items 1-6 of 6
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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
(Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
(2007)The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ... -
Investigation of the central serotonergic system in the olfactory bulbectomized rat model of depression
(2017-11-10)Depression is a devastating heterogeneous disease that has a high lifetime prevalence. Despite over 50 years of research, the aetiology of depression is still largely undetermined but the improper functioning of the central ... -
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
(Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ...