Browsing by Author "O'Byrne, Conor P."
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Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance
Boyd, Aoife; Abram, Florence; Karatzas, Kimon-andreas; Matlawska-Wasowska, Ksenia; Connolly, David; O'Byrne, Conor P.; Starr, Emily (American Society for Microbiology, 2008-09)Sigma B is an alternative sigma factor that controls the transcriptional response to stress in Listeria monocytogenes and is also known to play a role in the virulence of this human pathogen. In the present study we ... -
Loss of sigb in listeria monocytogenes strains egd-e and 10403s confers hyperresistance to hydrogen peroxide in stationary phase under aerobic conditions
Boura, Marcia; Keating, Ciara; Royet, Kevin; Paudyal, Ranju; O'Donoghue, Beth; O'Byrne, Conor P.; Karatzas, Kimon A. G. (American Society for Microbiology, 2016-05-20)SigB is the main stress gene regulator in Listeria monocytogenes affecting the expression of more than 150 genes and thus contributing to multiple-stress resistance. Despite its clear role in most stresses, its role in ... -
A molecular genetic investigation into stress sensing in the food-borne pathogen Listeria Monocytogenes: roles for RsbR and its paralogues
O'Donoghue, Beth (2016-11-30)The alternative sigma factor σB is conserved across several Gram-positive bacteria species as the major general stress response (GSR) regulator. For the food-borne pathogen Listeria monocytogenes, σB enables the bacterium ... -
Thiamine plays a critical role in the acid tolerance of listeria monocytogenes
Madeo, Moira; O'Riordan, Niamh; Fuchs, Thilo M.; Utratna, Marta; Karatzas, Kimon Andreas G.; O'Byrne, Conor P. (Oxford University Press (OUP), 2011-11-14)Understanding the molecular basis of acid tolerance in the food-borne pathogen Listeria monocytogenes is important as this property contributes to survival in the food-chain and enhances survival within infected hosts. The ... -
The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis
Matlawska-Wasowska, Ksenia; Finn, Rebecca; Mustel, Ana; O'Byrne, Conor P.; Boyd, Aoife (BioMed Central, 2011)Background:Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type III Secretion Systems (TTSS) that deliver effector ...