Browsing by Author "Moureau, Sylvie"

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Regulation and function of the tumour suppressor 53BP1 at sites of DNA damage

Moureau, Sylvie (2013-10-16)

Cancer is the major cause of death for people in middle age. It results from cell transformation into malignant cells and propagates with normal controls. This process is induced by mutations occurring in DNA through the ...
Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor

FitzGerald, Jennifer; Moureau, Sylvie; O'Connell, Enda; Grenon, Muriel; Muriel, Noel F. (PLoS, 2011-02)

Background Dot1L, a histone methyltransferase that targets histone H3 lysine 79 (H3K79), has been implicated in gene regulation and the DNA damage response although its functions in these processes remain poorly ...