Browsing by Subject "Mesenchymal stem cells"
Now showing items 1-20 of 27
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Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
(2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Chondrogenic and vascular priming: an endochondral ossification approach to bone tissue regeneration
(2015-11-30)Tissue engineering and regenerative medicine have significant potential to treat bone pathologies by exploiting the capacity for bone progenitors to grow and produce tissue constituents under specific biochemical and ... -
Development of next generation MSC therapeutics for critical limb ischaemia
(2015-02-19)Cell therapy with mesenchymal stem cells (MSCs) is being explored as a treatment for many ischaemic conditions of unmet medical need, such as critical limb ischaemia. MSC transplantation in humans has occurred in both ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley, 2016-02-27)The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ... -
The effect of substrate stiffness, thickness, and cross-linking density on osteogenic cell behavior
(Biophysical Society, 2015-04-07)Osteogenic cells respond to mechanical changes in their environment by altering their spread area, morphology, and gene expression profile. In particular, the bulk modulus of the substrate, as well as its microstructure ... -
Effects of in vitro endochondral priming and pre-vascularisation of human MSC cellular aggregates in vivo
(2015)Introduction: During endochondral ossification, both the production of a cartilage template and the subsequent vascularisation of that template are essential precursors to bone tissue formation. Recent studies have found ... -
Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect
(Springer Verlag, 2015-01-15)The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an ... -
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
(NUI Galway, 2019-02-15)The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ... -
Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model
(Springer Verlag, 2015-10-05)Cartilage tissue engineering is a multifactorial problem requiring a wide range of material property requirements from provision of biological cues to facilitation of mechanical support in load-bearing diarthrodial joints. ... -
Genetically modified mesenchymal stem cells overexpressing CCR2 for cell therapy in critical limb ischemia
(2017-09-21)Critical Limb Ischemia (CLI) is an advanced stage of Peripheral Arterial Disease (PAD) and a global health problem. Patients with CLI may present with rest pain, gangrene and/or ulceration of the lower limb. Effective ... -
Immunogenicity of allogeneic mesenchymal stem cells
(2012)Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ... -
Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis
(2015-03-06)Although osteoarthritis (OA) is typically characterised by the loss or damage to articular cartilage, inflammation of the synovial membrane is now recognised as a prevalent feature believed to contribute to both symptoms ... -
Immunomodulation of the T-helper 17 Cell Lineage by Mesenchymal Stem Cells
(2012-11-20)T-helper 17 (Th17) cells play a pathogenic role in multiple sclerosis, inflammatory bowel disease, psoriasis, acute kidney injury, glomerulonephritis and transplant rejection. Mesenchymal stem cells (MSCs) are immunosuppressive ... -
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy
(Wiley, 2013-08-07)Recent in vitro tissue engineering approaches have shown that chondrogenic priming of human bone marrow mesenchymal stem cells (MSCs) can have a positive effect on osteogenesis in vivo. However, whether chondrogenic ... -
Meseanchymal stem cell mediated sodium iodide symporter gene therapy of breast cancer
(2014-05-07)Introduction: The Sodium Iodide Symporter (NIS) facilitates iodide accumulation in the thyroid and radioiodide imaging and treatment of thyroid disease. Studies have suggested that elevated levels of NIS expression in ... -
Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation
(Lippincott, Williams & Wilkins, 2016-12)PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival. RECENT FINDINGS: To date, only small numbers studies have ... -
Mesenchymal stem cells for therapeutic application in corneal transplantation
(2014-02-12)Although corneal transplantation success rates are high within the first year, the prognosis is much less favourable 5 years post-transplantation with immune-mediated rejection the primary cause of allograft failure. For ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
(AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
(AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ...