Browsing by Author "Lahue, Robert S."
Now showing items 1-11 of 11
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A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal cag repeat expansions in huntington’s disease mice
Suelves, Nuria; Kirkham-McCarthy, Lucy; Lahue, Robert S.; Ginés, Silvia (Springer Nature, 2017-07-20)Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The ... -
Expansions of CAG·CTG repeats in immortalized human astrocytes.
Lahue, Robert S. (Oxford University Press, 2007)Expansions of trinucleotide repeats (TNRs) are the genetic cause for a number of neurodegenerative disorders. In some of these diseases, ongoing somatic expansions in the brain are thought to contribute to disease progression. ... -
Histone deacetylase complexes as caretakers of genome stability
Lahue, Robert S.; Frizzell, Aisling (Informa UK Limited, 2012-08-18) -
Mrc1, tof1 and csm3 inhibit cag·ctg repeat instability by at least two mechanisms
Razidlo, David F.; Lahue, Robert S. (Elsevier BV, 2008-04-01)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion rates. ... -
Mrc1, Tof1 and Csm3 inhibit CAG·CTG repeat instability by at least two mechanisms
Lahue, Robert S. (Springer, 2008)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion ... -
Mutsβ abundance and msh3 atp hydrolysis activity are important drivers of ctg•cag repeat expansions
Keogh, Norma; Chan, Kara Y.; Li, Guo-Min; Lahue, Robert S. (Oxford University Press (OUP), 2017-07-21)CTG circle CAG repeat expansions cause at least twelve inherited neurological diseases. Expansions require the presence, not the absence, of the mismatch repair protein MutS beta (Msh2-Msh3 heterodimer). To evaluate ... -
Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
Gannon, Anne-Marie M.; Frizzell, Aisling; Healy, Evan; Lahue, Robert S. (Oxford University Press (OUP), 2012-08-30)Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ... -
Partial reconstitution of dna large loop repair with purified proteins from saccharomyces cerevisiae
Sommer, Debbie; Stith, Carrie M.; Burgers, Peter M. J.; Lahue, Robert S. (Oxford University Press (OUP), 2008-07-15)Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ... -
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae
Lahue, Robert S. (OUP, 2008)Small looped mispairs are corrected by DNA mismatch repair. In addition, a distinct process called large loop repair (LLR) corrects heteroduplexes up to several hundred nucleotides in bacteria, yeast and human cells, and ... -
Rapid unwinding of triplet repeat hairpins by srs2 helicase of saccharomyces cerevisiae
Dhar, Alok; Lahue, Robert S. (Oxford University Press (OUP), 2008-04-25)Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ... -
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae
Lahue, Robert S. (2008)Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ...