Browsing by Author "Kennedy, Donna"
Now showing items 1-6 of 6
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Heat shock preconditioning protects against er stress-induced apoptosis through the regulation of the bh3-only protein bim
Kennedy, Donna; Mnich, Katarzyna; Samali, Afshin (Wiley-Blackwell, 2014-01-01) -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
Kennedy, Donna; Mnich, Katarzyna; Oommen, Deepu; Chakravarthy, Reka; Almeida-Souza, Leonardo; Krols, Michiel; Saveljeva, Svetlana; Doyle, Karen M.; Gupta, Sanjeev; Timmerman, Vincent; Janssens, Sophie; Gorman, Adrienne M.; Samali, Afshin (Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
Regulation of apoptosis by heat shock proteins
Kennedy, Donna; Jäger, Richard; Mosser, Dick D; Samali, Afshin (Wiley-Blackwell, 2014-05-01) -
The regulation of ER stress induced cell death by HSPB1 (hsp27)
Kennedy, Donna (2013-01-29)Endoplasmic reticulum (ER) stress is associated with several human pathologies including neurodegenerative disorders. ER stress results in accumulation of unfolded proteins which activates the unfolded protein response ... -
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
Doyle, Karen M.; Kennedy, Donna; Gorman, Adrienne M.; Gupta, Sanjeev; Healy, Sandra J. M.; Samali, Afshin (Wiley-Blackwell, 2011-09-26)The stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, ... -
Vascular plasticity and target for therapy in Duchenne muscular dystrophy
Kennedy, Donna (NUI Galway, 2023-06-13)Angiogenesis is the growth of new blood vessels from pre-existing vessels, necessary for the growth and maintenance of homeostasis. Duchenne muscular dystrophy (DMD) is a debilitating disease of the musculoskeletal ...