Now showing items 1-3 of 3

  • Functional role of CCAN histone fold proteins in mitosis 

    Kaczmarczyk, Agnieszka (2012-05-31)
    Centromeres are chromosomal loci that direct segregation of the genome by specifying kinetochore assembly in mitosis and meiosis. Kinetochores are built upon centromeric chromatin, which contains the histone H3 variant ...
  • Premitotic Assembly of Human CENPs -T and -W Switches Centromeric Chromatin to a Mitotic State. 

    Prendergast, Lisa; van Vuuren, Chelly; Kaczmarczyk, Agnieszka; Quinn, Nadine; Sullivan, Kevin F. (2011)
    Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that ...
  • Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint 

    Maffini, Stefano; Rainey, Michael D.; Kaczmarczyk, Agnieszka; O'Connor, Aisling; Gaboriau, David; Musacchio, Andrea; Santocanale, Corrado (Company of Biologists, 2016)
    During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ...