Browsing by Subject "In vivo"
Now showing items 1-9 of 9
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Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
(Biophysical Society, 2015-04-07)Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ... -
Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit
(Elsevier, 2010-03-21)Single channel conduits are used clinically in nerve repair as an alternative to the autologous nerve graft. Axons regenerating across single channel tubes, however, may disperse resulting in inappropriate target reinnervation. ... -
Differentiation of vascular stem cells contributes to ectopic calcification of atherosclerotic plaque
(Wiley, 2016-02-27)The cellular and molecular basis of vascular calcification (VC) in atherosclerosis is not fully understood. Here, we investigate role of resident/circulating progenitor cells in VC and contribution of inflammatory plaque ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
(Elsevier, 2012-06-25)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
Measuring the linear and nonlinear elastic properties of brain tissue with shear waves and inverse analysis
(Springer, 2015-02-20)We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the ... -
Mechanical characterization of brain tissue in simple shear at dynamic strain rates
(Elsevier, 2013-12)During severe impact conditions, brain tissue experiences a rapid and complex deformation, which can be seen as a mixture of compression, tension and shear. Diffuse axonal injury (DAI) occurs in animals and humans when ... -
Mechanical characterization of brain tissue in tension at dynamic strain rates
(Elsevier, 2012-09-10)Mechanical characterization of brain tissue at high loading velocities is crucial for modeling Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences compression, tension and shear. Limited ... -
Thermally induced osteocyte damage initiates a remodelling signaling cascade
(Public Library of Science, 2015-03-18)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ... -
Understanding the changes of cone reflectance in adaptive optics flood illumination retinal images over three years
(Optical Society of America, 2016)Although there is increasing interest in the investigation of cone reflectance variability, little is understood about its characteristics over long time scales. Cone detection and its automation is now becoming a fundamental ...