Browsing by Author "Higgins, Brendan D"
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Effects and mechanisms of action of sildenafil citrate in human chorionic arteries
Maharaj, Chrisen H; O'Toole, Daniel; Lynch, Tadhg; Carney, John; Jarman, James; Higgins, Brendan D; Morrison, John J; Laffey, John G (Springer Nature, 2009-01-01)Objectives: Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine ... -
Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury
Kennedy, Muiris T; Higgins, Brendan D; Costello, Joseph F; Curtin, William A; Laffey, John G (BioMed Central Ltd., 2008-07-08)Background: Hypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung ...