Browsing by Author "Haugh, Matthew G."
Now showing items 1-7 of 7
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Altered mechanical environment of bone cells in an animal model of short- and long-term osteoporosis
Verbruggen, Stefaan W.; McGarrigle, Myles J.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (Biophysical Society, 2015-04-07)Alterations in bone tissue composition during osteoporosis likely disrupt the mechanical environment of bone cells and may thereby initiate a mechanobiological response. It has proved challenging to characterize the ... -
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
Freeman, Fiona E.; Haugh, Matthew G.; McNamara, Laoise M. (Mary Ann Liebert, 2015-03-03)Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ... -
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy
Freeman, Fiona E.; Haugh, Matthew G.; McNamara, Laoise M. (Wiley, 2013-08-07)Recent in vitro tissue engineering approaches have shown that chondrogenic priming of human bone marrow mesenchymal stem cells (MSCs) can have a positive effect on osteogenesis in vivo. However, whether chondrogenic ... -
Osteocyte differentiation and the formation of an interconnected cellular network in vitro
Mc Garrigle, M.J.; Mullen, Conleth A.; Haugh, Matthew G.; Voisin, Muriel C.; McNamara, Laoise M. (AO Research Institute Davos, 2016-05-26)Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ... -
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separation
Mullen, Conleth A.; Haugh, Matthew G.; Schaffler, M. B.; Majeska, R. J.; McNamara, Laoise M. (Elsevier, 2013-07-18)Osteocytes are terminally differentiated bone cells, derived from osteoblasts, which are vital for regulation of bone formation and resorption. ECM stiffness and cell seeding density have been shown to regulate osteoblast ... -
The role of integrin αVβ3 in osteocyte mechanotransduction
Haugh, Matthew G.; Vaughan, Ted J.; McNamara, Laoise M. (Elsevier, 2014-11-10)Recent in vivo studies have proposed that integrin alpha(v)beta(3) attachments between osteocyte cell processes and the extracellular matrix may facilitate mechanosensation in bone. However the role of these attachments ... -
Thermally induced osteocyte damage initiates a remodelling signaling cascade
Dolan, Eimear B.; Haugh, Matthew G.; Voisin, Muriel C.; Tallon, David; McNamara, Laoise M. (Public Library of Science (PLoS), 2015-03-18)Thermal elevations experienced by bone during orthopaedic procedures, such as cutting and drilling, exothermal reactions from bone cement, and thermal therapies such as tumor ablation, can result in thermal damage leading ...