Browsing by Author "Glynn, Sharon"
Now showing items 1-10 of 10
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Characterisation of the molecular and functional changes exerted on human bone marrow mesenchymal stem cells by prostate cancer cells
Ridge, Sarah (2016-07-01)Mesenchymal stem cells (MSCs) are a heterogenous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. MSCs reside in various areas such as the bone marrow, ... -
Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype
Burke, Amy (2015-11-05)Prostate cancer is the second most commonly diagnosed cancer, and ranked third in the causes of death from cancer in Irish men. Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 ... -
Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery – a pilot study
Galbraith, Adam Samuel; Sanz-Nogués, Clara; Glynn, Sharon; Coleman, Cynthia M.; Murphy, Colin (Wiley, 2019-11-07)Diabetes mellitus (DM) is associated with an elevated risk of post-operative complications. The impact it has on patients living with DM following hip fracture surgery (HFS) is not completely understood, and may represent ... -
Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer
Ali, Husnain (2016-11-30)Glycogen Synthase Kinase 3 (GSK3) is involved in a myriad of signalling pathways and has recently received considerable interest due to its conflicting roles tumourigenesis. Though it has classically been regarded as a ... -
Gene expression profiles of no- and hno-donor treated breast cancer cells: insights into tumor response and resistance pathways
Cheng, Robert Y.S.; Basudhar, Debashree; Ridnour, Lisa A.; Heinecke, Julie L.; Kesarwala, Aparna H.; Glynn, Sharon; Switzer, Christopher H.; Ambs, Stefan; Miranda, Katrina M.; Wink, David A. (Elsevier BV, 2014-12-01)Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates disease progression via NO in a number of pathologies, including cancer. The role of NOS2-derived NO is not only flux-dependent, which is higher ... -
Human endogenous retrovirus K (HERV-K) in prostate cancer
Downey, Rónán (2016-08-08)Millions of years of infection by viral agents have left their mark on the human genome in the form of human endogenous retroviruses (HERVs). These retroelements integrated into our germline, became subject to Mendelian ... -
Investigating the mechanism of action and potential efficacy of Apolipoprotein E mimetics as therapeutic agents for the treatment of metastatic prostate cancer
Johnson, Carol (2017-10-04)Prostate cancer is the most prevalent non cutaneous cancer diagnosed in Irish men and the third leading cause of death in males annually in Ireland. Therapeutic strategies currently consist of prostatectomy or radiation ... -
Molecular impact of Human Endogenous Retrovirus K (HERV-K) on breast cancer progression
Bhattacharyya, Dibyangana (NUI Galway, 2021-07-28)Viruses have left their mark on the human genome over millions of years in the form of human endogenous retroviruses (HERVs). These retroelements inserted themselves into our germline, became inherited in a Mendelian ... -
Preclinical assessment of the novel compound EL102 in prostate cancer
Toner, Aidan (2015-03-31)Prostate cancer remains a growing problem for the male population, globally. Though there have been clinical advances in recent years, there still remains a need to develop drugs that can slow or stop progression beyond ... -
Signaling and stress: the redox landscape in nos2 biology
Thomas, Douglas D.; Heinecke, Julie L.; Ridnour, Lisa A.; Cheng, Robert Y.; Kesarwala, Aparna H.; Switzer, Christopher H.; McVicar, Daniel W.; Roberts, David D.; Glynn, Sharon; Fukuto, Jon M.; Wink, David A.; Miranda, Katrina M. (Elsevier BV, 2015-10-01)