Browsing by Subject "Genetics"
Now showing items 1-6 of 6
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Advancing Science and Controlling the Misuse of Genetic Information in Employment and Insurance - Towards an Effective European Union Regulatory Framework
(2013-08-28)The science of genetic testing and related technology is rapidly advancing. Among other things, genetic testing technology may offer the prospect of being able to detect the onset of future disabilities. It also offers ... -
Computational Selection of Transcriptomics Experiments Improves Guilt-by-Association Analyses
(PLos ONE, 2012-08-07)The Guilt-by-Association (GBA) principle, according to which genes with similar expression profiles are functionally associated, is widely applied for functional analyses using large heterogeneous collections of transcriptomics ... -
Identification and characterisation of germline variants in an Irish cohort with breast cancer
(NUI Galway, 2020-02-10)Breast cancer is the most common female malignancy worldwide, and the second most common cause of cancer-related deaths in women. Twin studies estimate that up to one third of breast cancers are the result of hereditary ... -
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
(Nature Publishing Group (Macmillan), 2013-04)TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ... -
Neurocognitive effects of risk factors for psychosis: Neuropsychological and neuroimaging studies of immune-related genetic and environmental factors
(NUI Galway, 2020-04-16)Schizophrenia (SZ) is a debilitating psychiatric disorder that afflicts approximately 1% of people worldwide. It is often characterized by hallucinations, sometimes by emotional blunting, and in a majority of cases by a ... -
Upregulation of PSCDBP, TLR2, TWIST1, FLJ35382, EDNRB, and RGS12 gene expression in human myometrium at labor.
(Sage, 2008)The regulatory mechanisms underlying myometrial smooth muscle contractility during labor are poorly understood. The authors therefore investigated the transcriptional profile of the changes that occur in the human myometrium ...