Browsing by Subject "Gene expression"
Now showing items 1-15 of 15
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Acute phase gene expression in rainbow trout (Oncorhynchus mykiss) after exposure to a confinement stressor: A comparison of pooled and individual data
(Elsevier, 2009-06-09)This study set out to investigate whether differential expression of genes for acute phase proteins in rainbow trout (Oncorhynchus mykiss) could be induced by confinement stress, a non-invasive method of activating the ... -
Analyzing time-course microarray data using functional data analysis - a review
(Statistical Applications in Genetics and Molecular Biology, 2011-05)Gene expression over time can be viewed as a continuous process and therefore represented as a continuous curve or function. Functional data analysis (FDA) is a statistical methodology used to analyze functional data ... -
A cDNA microarray assessment of gene expression in the liver of rainbow trout (Oncorhynchus mykiss) in response to a handling and confinement stressor
(Elsevier, 2008-03)A purpose-designed microarray platform (Stressgenes, Phase 1) was utilised to investigate the changes in gene expression within the liver of rainbow trout during exposure to a prolonged period of confinement. Tissue and ... -
Ceratopteris richardii (C-Fern): a model for investigating adaptive modification of vascular plant cell walls
(Frontiers Media, 2013-09-23)Plant cell walls are essential for most aspects of plant growth, development, and survival, including cell division, expansive cell growth, cell-cell communication, biomechanical properties, and stress responses. Therefore, ... -
Clinical Applications of Molecular Profiling in Colorectal Cancer
(2011-06)Despite developments in diagnosis and treatment, 20% of colorectal cancer (CRC) patients present with metastatic disease and 30% of cases recur after curative surgery. Furthermore, the molecular factors involved in prognosis ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
Differential β3 and β1 integrin expression in bone marrow and cortical bone of estrogen deficient rats
(Wiley, 2015-08-12)Integrin-based (beta(3)) attachments to the extracellular matrix (ECM) on osteocyte cell processes have recently been proposed to play an important role in facilitating osteocyte mechanosensation. However, it is not yet ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
(American Physiological Society, 2016-01-01)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ... -
Estimation and analysis of gene expression and alternative splicing: perspectives from development and disease
(2014-01-30)The development of high-throughput genomics technologies has contributed substantially to the understanding of gene expression regulation. With the growing appreciation of the importance of alternative splicing, quantitative ... -
An in vitro bone tissue regeneration strategy combining chondrogenic and vascular priming enhances the mineralization potential of mesenchymal stem cells In vitro while also allowing for vessel formation
(Mary Ann Liebert, 2015-03-03)Chondrogenic priming (CP) of mesenchymal stem cells (MSCs) and coculture of MSCs with human umbilical vein endothelial stem cells (HUVECs) both have been shown to significantly increase the potential for MSCs to undergo ... -
Investigation of intron coevolution and the autoimmune potential of alternative splicing
(2016-07-20)Introns are non-coding intergenic sequences that are routinely excised from nascent pre-mRNA transcripts by a process known as splicing. Although they do not contribute directly to the protein-coding sequences of genes, ... -
Novel insights into the molecular roles of UBP5 in controlling chromatin dynamics and plant development
(NUI Galway, 2023-04-03)Polycomb group (PcG) proteins are conserved chromatin regulators essential for controlling key developmental programs in eukaryotes. PcG proteins assemble together to form multi-protein complexes known as Polycomb ... -
Regulation Of Myometrial Gene Expression By Oestrogen And Progesterone: The Use Of A Cell Culture Model To Mimic The In Vivo Conditions Of Pregnant Human Uterus
(2012-12-31)Pregnancy and labour are physiological events controlled by a complex interplay between maternal and foetal factors. These processes are diverse and specific to each species, hence simple extrapolation from model organisms ... -
Wnt signalling in the hydrozoan Hydractinia echinata
(2013-09-11)Canonical Wnt signalling controls many developmental processes in metazoans including primary axis formation in embryonic development and stem cell decision making. The evolutionary history of Wnt signalling and its ancestral ...