Now showing items 1-3 of 3

  • Endoplasmic reticulum stress signalling in myelination 

    Naughton, Michelle (2017-12-07)
    Demyelinating conditions such as multiple sclerosis have a continued unmet need for remyelinating therapies. Myelin is a multi-lamellar membrane structure made by oligodendrocyte progenitor cells (OPCs) that is critical ...
  • Ex vivo investigation of iron handling in the brain 

    Healy, Sinead (2016-11-04)
    Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ...
  • Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response 

    Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)
    The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ...