Browsing by Author "FitzGerald, Una"
Now showing items 1-10 of 10
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A lifetime of stress: atf6 in development and homeostasis
Hillary, Robert F.; FitzGerald, Una (Springer Nature, 2018-05-25)Background: Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked ... -
ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+
Bandla, Sravanthi; Diaz, Suraya; Nasheuer, Heinz-Peter; FitzGerald, Una (Wiley Open Access, 2019-08-29)B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone normally found in the ER lumen. However, BiP also has other extracellular and intracellular functions. As it is unclear whether ... -
Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination
Ní Fhlathartaigh, Mary; McMahon, Jill; Reynolds, Richard; Connolly, David; Higgins, Eibhlín; Counihan, Timothy; FitzGerald, Una (Springer Nature, 2013-01-01)Background: Calreticulin (CRT) is a chaperone protein, which aids correct folding of glycosylated proteins in the endoplasmic reticulum (ER). Under conditions of ER stress, CRT is upregulated and may be displayed on the ... -
Cd95-mediated alteration in hsp70 levels is dependent on protein stabilization
Concannon, Caoimhín G.; FitzGerald, Una; Holmberg, Carina I.; Szegezdi, Eva; Sistonen, Lea; Samali, Afshin (Springer Nature, 2005-01-01)Engagement of death receptors induces caspase activation and apoptosis. A recent study reported altered protein expression, including increased Hsp70 levels during CD95-mediated apoptosis. Here, we examined the mechanism ... -
Effects of exogenous B-cell immunoglobulin binding protein (BIP) and BIP protein inducer X (BIX) on myelination
Bandla, Sravanthi (NUI Galway, 2019-12-12)B-cell immunoglobulin binding protein (BiP) is an essential endoplasmic reticulum (ER) chaperone that belongs to the Hsp70 family, normally found in the ER lumen. However, BiP also has other extracellular and intracellular ... -
Endoplasmic reticulum stress signalling in myelination
Naughton, Michelle (2017-12-07)Demyelinating conditions such as multiple sclerosis have a continued unmet need for remyelinating therapies. Myelin is a multi-lamellar membrane structure made by oligodendrocyte progenitor cells (OPCs) that is critical ... -
Ex vivo investigation of iron handling in the brain
Healy, Sinead (2016-11-04)Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ... -
Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
Mháille, Aoife Ní; McQuaid, Stephen; Windebank, Anthony; Cunnea, Paula; McMahon, Jill; Samali, Afshin; FitzGerald, Una (Oxford University Press (OUP), 2008-03-01)Activation of endoplasmic reticulum (ER) stress-related cell signals has been reported in several neurologic disorders and may contribute to neurodegeneration. Endoplasmic reticulum stress is also linked to ischemic injury. ... -
Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response
Samali, Afshin; FitzGerald, Una; Deegan, Shane; Gupta, Sanjeev (2010)The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and ... -
Prodromal Parkinson’s disease, DOPAL and the olfactory bulb: from an organotypic model to clinical relevance
Bagnoli, Enrico (NUI Galway, 2020-09)Parkinson’s disease (PD) is an untreatable neurodegenerative disorder affecting more than six million people worldwide, a figure expected to more than double within a generation. The causes of PD are still largely unknown ...