Browsing by Author "Finn, David"
Now showing items 1-8 of 8
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Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
Burke, Nikita (2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Development and characterisation of a novel, anatomically relevant rat model of acute postoperative pain
Bree, Dara (2014-09-30)Acute postoperative pain remains a significant healthcare issue, delaying discharge and prolonging convalescence periods, resulting in high social and economic costs. Depending on the type of surgical procedure performed, ... -
Novel approaches to the understanding and treatment of postoperative pain
Power, Emer (NUI Galway, 2019-12-06)Postoperative pain constitutes a significant medical need. Greater understanding of the mechanisms will allow for more effective treatments. The endogenous cannabinoid (endocannabinoid) and opioid systems play a key role ... -
Optogenetic investigations into the role of glutamatergic neurons of the anterior cingulate cortex in sensory and affective components of pain
Jarrin, Sarah (NUI Galway, 2019-11-15)Pain consists of sensory-discriminative and affective-motivational components, which can share a reciprocal relationship. The anterior cingulate cortex (ACC) plays an important role in top-down control and the affective ... -
Regulation of fear, anxiety and cognition in the presence or absence of pain by peroxisome proliferator-activated receptors
Gaspar, Jessica (NUI Galway, 2019-06-07)Fear/anxiety and pain modulate one another reciprocally, but the neurobiological mechanisms that underlie this interaction are not completely understood. Fear-conditioned analgesia (FCA) is pain suppression upon exposure ... -
The role of the endocannabinoid system in the affective modulation of pain
Jennings, Elaine (2015-09-30)Pain represents a major unmet clinical need and affects a large number of individuals worldwide. Numerous studies indicate a very high prevalence of chronic pain comorbid with psychiatric disorders such as anxiety and ... -
The role of the endocannabinoid system in the emotional modulation of pain
Corcoran, Louise (NUI Galway, 2018-09-06)Fear-conditioned analgesia (FCA) is the robust suppression of pain that occurs upon reexposure to a context previously paired with an aversive stimulus. FCA is mediated by activation of the descending inhibitory pain ... -
The role of the endogenous opioid system in hyperalgesia associated with negative affect
Ferdousi, Mehnaz (NUI Galway, 2020-02-26)Pain and negative affect (anxiety and depression) modulate one another reciprocally. However, the neurobiological mechanisms underlying this interaction are unclear. The endogenous opioid system plays a key role in regulating ...