Browsing by Author "Fearnhead, Howard O."
Now showing items 1-5 of 5
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Dna-pk activity is associated with caspase-dependent myogenic differentiation
Connolly, Patrick F.; Fearnhead, Howard O. (Wiley-Blackwell, 2016-10-01)Differentiation of myoblasts into myotubes is essential for skeletal muscle development and regeneration. Caspase-3 and caspase-9 are required for efficient myoblast differentiation. The caspase-activated endonuclease ... -
Identification of compounds that may be repurposed for the treatment of triple negative breast cancer
Monaghan, David A. (2012-11-21)Triple negative breast cancers (TNBC), lack the estrogen and progesterone receptors as well as the HER2 receptor. Currently, there is no selective therapy for the treatment of TNBC and current treatment regimens rely on a ... -
Inhibition of protein synthesis and jnk activation are not required for cell death induced by anisomycin and anisomycin analogues
Monaghan, David; O’Connell, Enda; Cruickshank, Faye L.; O’Sullivan, Barry; Giles, Francis J.; Hulme, Alison N.; Fearnhead, Howard O. (Elsevier BV, 2014-01-01) -
New roles for old enzymes: killer caspases as the engine of cell behavior changes
Connolly, Patrick F.; Jäger, Richard; Fearnhead, Howard O. (Frontiers Media SA, 2014-04-16)It has become increasingly clear that caspases, far from being merely cell death effectors, have a much wider range of functions within the cell. These functions are as diverse as signal transduction and cytoskeletal ... -
P53-mediated induction of noxa and p53aip1 requires nfκb
O’Prey, Jim; Crighton, Diane; Martin, Angel G.; Vousden, Karen H.; Fearnhead, Howard O.; Ryan, Kevin M. (Informa UK Limited, 2010-03-01)The intricate regulation of cell survival and cell death is critical for the existence of both normal and transformed cells. Two factors central to these processes are p53 and NF kappa B, with both factors having ascribed ...