Browsing by Subject "Endoplasmic reticulum stress"
Now showing items 1-4 of 4
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A cell-based study exploring novel therapeutic approaches to target cell stress and cell death pathways in paediatric cancers
(NUI Galway, 2020-08-17)Paediatric cancer is the leading cause of death by disease in children. High mortality rates and long-term effects of conventional treatments suggest an urgent need for basic and translational research to allow treatment ... -
Cellular responses to endoplasmic reticulum stress: Role of autophagy and cell death
(2014-12-03)This PhD thesis describes cellular responses to the induction of endoplasmic reticulum (ER) stress, focusing on the role of autophagy and cell death. Pro-survival role of unfolded protein response (UPR) is analysed by ... -
Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
(Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Endoplasmic Reticulum Stress as a Component of Demyelination in Animal Models of Multiple Sclerosis
(2012-12-19)Endoplasmic reticulum (ER) stress is a homeostatic signalling pathway, linked to many neurological diseases including multiple sclerosis (MS), which can lead to cell death when prolonged. Increasing evidence suggests that ...