Browsing by Author "Dwyer, Róisín M."
Now showing items 1-20 of 47
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Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
Dwyer, Róisín M.; Bergert, Elizabeth R.; O'Connor, Michael K.; Gendler, Sandra J.; Morris, John C. (Mary Ann Liebert, 2006-06-15)Pancreatic cancer is the fourth leading cause of cancer death in the United States. It is highly aggressive with no uniformly effective chemotherapy available for metastatic disease. The sodium–iodide symporter (NIS) is a ... -
Advances in mesenchymal stem cell-mediated gene therapy for cancer
Dwyer, Róisín M.; Khan, Sonja; Barry, Frank P; O'Brien, Timothy; Kerin, Michael J (Springer Nature, 2010-01-01)Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their ... -
Analysis of cytokine expression in breast cancer
Hartmann, Marion Charlotte (2014-10-29)Introduction: It has long been recognized that cancer develops in sites of chronic inflammation. Tumours seem to seize molecular pathways seen in wound healing and the inflammatory response and as a consequence appear as ... -
Characterization of nanosensitive multifractality in submicron scale tissue morphology and its alteration in tumor progression
Das, Nandan; Alexandrov, Sergey; Gilligan, Katie E.; Dwyer, Róisín M.; Saager, Rolf B.; Ghosh, Nirmalya; Leahy, Martin (Society of Photo-optical Instrumentation Engineers, 2021-01-11)Significance: Assessment of disease using optical coherence tomography is an actively investigated problem, owing to many unresolved challenges in early disease detection, diagnosis, and treatment response monitoring. The ... -
Circulating MicroRNAs in cancer
O’Brien, Killian P.; Ramphul, Eimear; Howard, Linda; Gallagher, William M.; Malone, Carmel; Kerin, Michael J.; Dwyer, Róisín M. (Humana Press, 2016-11-09)It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating MiRNAs
Kelly, Helena; Downing, Tim; Tuite, Nina; Smith, Terry; Kerin, Michael; Dwyer, Róisín M.; Clancy, Eoin; Reddington, Kate; Barry, Thomas (Public Library of Science, 2015-09-10)Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed as biomarkers ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating mirnas
Kelly, Helena; Downing, Tim; Tuite, Nina L.; Smith, Terry J.; Kerin, Michael J.; Dwyer, Róisín M.; Clancy, Eoin; Barry, Thomas; Reddington, Kate (Public Library of Science (PLoS), 2015-09-10)Introduction Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed ... -
Current and potential diagnostic modalities in the detection and management of breast cancer
Moloney, Brian Michael (NUI Galway, 2021-07-06)Global statistics have demonstrated that breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among female patients, accounting for 23 percent of total cancer cases and 14 percent of ... -
Design and performance of a small-animal imaging system using synthetic collimation
Havelin, R J; Miller, B W; Barrett, H H; Furenlid, L R; Murphy, J M; Dwyer, Róisín M.; Foley, M J (IOP Publishing, 2013-04-26)This work outlines the design and construction of a single-photon emission computed tomography imaging system based on the concept of synthetic collimation. A focused multi-pinhole collimator is constructed using ... -
Development of 3D breast cancer model to study extracellular vesicle crosstalk
Chabria, Yashna (NUI Galway, 2024-01-31)3D model systems are crucial in establishing novel therapeutics and understanding cell interactions in the tumor microenvironment. Extracellular vesicles (EVs) are promising carriers of therapeutic cargo for tumor-targeted ... -
Diagnostic and therapeutic mesenchymal stem cells for breast cancer treatment
Dwyer, Róisín M. (Wiley, 2013-08-09)[No abstract available] -
Dysregulated mir-183 inhibits migration in breast cancer cells
Lowery, Aoife J; Miller, Nicola; Dwyer, Róisín M.; Kerin, Michael J (Springer Nature, 2010-09-21)Background: The involvement of miRNAs in the regulation of fundamental cellular functions has placed them at the fore of ongoing investigations into the processes underlying carcinogenesis. MiRNA expression patterns have ... -
Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
O’Brien, K. P.; Khan, S.; Gilligan, K. E.; Zafar, H.; Lalor, P.; Glynn, C.; O’Flatharta, C.; Ingoldsby, H.; Dockery, P.; De Bhulbh, A.; Schweber, J. R.; St John, K.; Leahy, M.; Murphy, J. M.; Gallagher, W. M.; O’Brien, T.; Kerin, Michael J.; Dwyer, Róisín M. (Springer Nature, 2018-01-25)Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ... -
Exosomal microRNAs in colorectal cancer
Clancy, Cillian (2016)Cancer cells have been shown to release a variety of extracellular membrane vesicles including microvesicles known as exosomes. Exosomes have recently been found to contain microRNAs (miRNAs) however the full range within ... -
Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer
Joyce, Doireann (2016-06-15)Breast cancer is a heterogeneous group of diseases survival from which depends on stage at diagnosis. The development of blood-based biomarkers which may facilitate earlier detection and possibly subtype delineation remains ... -
Exosome-encapsulated micrornas as circulating biomarkers for breast cancer
Joyce, Doireann P.; Kerin, Michael J.; Dwyer, Róisín M. (Wiley-Blackwell, 2016-05-31)Breast cancer is a highly prevalent disease, accounting for 29% of invasive cancers in women. Survival from this disease depends on the stage at diagnosis, with patients who are detected earlier having more favourable ... -
Extracellular vesicle encapsulated microRNAs and breast cancer
O'Neill, Clodagh (NUI Galway, 2023-02-24)Breast cancer is the most prevalent cancer among women worldwide. There is a clear need for earlier detection methods and more personalised treatments. Extracellular vesicle encapsulated microRNA (EV-miR) provide novel ... -
Impact of mesenchymal stem cell secreted pai-1 on colon cancer cell migration and proliferation
Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier BV, 2013-06-01) -
Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation
Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ... -
Impact of tumour epithelial subtype on circulating micrornas in breast cancer patients
Waters, Peadar S.; Dwyer, Róisín M.; Brougham, Cathy; Glynn, Claire L.; Wall, Deirdre; Hyland, Peter; Duignan, Maria; McLoughlin, Mark; Newell, John; Kerin, Michael J. (Public Library of Science (PLoS), 2014-03-13)While a range of miRNAs have been shown to be dysregulated in the circulation of patients with breast cancer, little is known about the relationship between circulating levels and tumour characteristics. The aim of this ...