Browsing by Author "Doyle, Karen M."
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Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report
Fitzgerald, Seán; Rizvi, Asim; Dai, Daying; Williamson, Eric E.; Lanzino, Giuseppe; Doyle, Karen M.; Kallmes, David F.; Brinjikji, Waleed (SAGE Publications, 2018-11-14)Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ... -
The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome
Rossi, Rosanna; Fitzgerald, Sean; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Santos, Andreia M. Silva; Murphy, Blathnaid; Alderson, Jack; Brennan, Paul; Power, Sarah; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, Andras; Vadasz, Agnes; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2020-09-16)Both intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatments for acute ischemic stroke (AIS) in selected cases. Recanalization may occur following IVT without the necessity of further ... -
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
Shearer, J. Andrew; Douglas, Andrew S.; Kirby, B. P.; Tatlisumak, Turgut; Doyle, Karen M. (Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Characterization of the ‘White’ appearing clots that cause acute ischemic stroke
Mereuta, Oana Madalina; Rossi, Rosanna; Douglas, Andrew; Molina Gil, Sara; Fitzgerald, Seán; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Eric; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; O'Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David F.; Szikora, Istvan; Rentzos, Alexandros; Tatlisumak, Turgut; Thornton, John; Doyle, Karen M. (Elsevier, 2021-09-28)Objectives Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the ... -
Considerations and recent advances in neuroscience
Gorman, Adrienne M.; Doyle, Karen M. (Portland Press Ltd., 2009-02-01)Neuroscience is a rapidly developing area of science which has benefitted from the blurring of interdisciplinary boundaries. This was apparent in the range of papers presented at this year's Neuroscience Ireland Conference, ... -
Dielectric profile of blood clots to inform ischemic stroke treatments
Santorelli, Adam; Fitzgerald, Seán; Douglas, Andrew; Doyle, Karen M.; O’Halloran, Martin (IEEE, 2020-07-20)Platelet and fibrin-rich blood clots can respond differently to red blood cell rich clots during ischemic stroke treatment, which includes thrombolysis and mechanical thrombectomy. Currently, there is no accurate way ... -
Does bridging therapy in mechanical thrombectomy increase recanalization rates in ischemic stroke patients affected by acute large vessel occlusion?
Silva Santos, Andreia M.; Rossi, Rosanna; Pandit, Abhay; Fitzgerald, Seán; Mereuta, Oana Madalina; Douglas, Andrew; Thornton, John; Brennan, Paul; Power, Sarah; O’Hare, Alan; Rentzos, Alexandros; Ceder, Erik; Tatlisumak, Turgut; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Duffy, Sharon; Gilvarry, Michael; McCarthy, Ray; Doyle, Karen M. (SAGE Publications, 2019-05-22)Both intravenous thrombolysis with tissue plasminogen activator (IV-rtPA) and mechanical thrombectomy (MT) increase recanalization rates. We assessed if bridging-therapy (the concomitant use of rtPA and MT) could increase ... -
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry
Rossi, Rosanna; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Fitzgerald, Seán; Tierney, Ciara; Pandit, Abhay; Brennan, Paul; Power, Sarah; O’Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, András; Vadász, Ágnes; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dunker, Dennis; Carlqvist, Jeanette; Psychogios, Klearchos; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2021-08-20)Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Doyle, Karen M. (Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Dockery, Peter; Doyle, Karen M. (Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
Devadasan, Carol; Starr, Beryl; Doyle, Karen M. (Lippincott, Williams & Wilkins, 2016-09-01)The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ... -
Fatty acid binding protein expression in clots retrieved by mechanical thrombectomy from patients with acute ischaemic stroke
Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andrew; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; O'Hare, Alan; Power, Sarah; Brennan, Paul; Rentzos, Alexandros; Tatlisumak, Turgut; Gunnarsson, Thorsteinn; Davidson, Maria; Brederlau, Anke; Allardt, Arne; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Sage Publications, 2019-05-22)Introduction: Lipid accumulation and inflammation are considered hallmarks of the unstable atherosclerotic plaque. In particular, adipocyte fatty acid binding protein (FABP4) expression within the plaque is associated ... -
Fear-induced suppression of nociceptive behaviour and activation of signal transduction molecules in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Butler, Ryan K.; Ford, Gemma K.; Hogan, Michelle; Roche, Michelle; Doyle, Karen M.; Kelly, John P.; Finn, David P. (Sage, 2011-09-17)The endocannabinoid system regulates nociception and aversion and mediates fear-conditioned analgesia (FCA). We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism ... -
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
Kavanagh, Edel T.; Loughlin, John P.; Herbert, Kate Reed; Dockery, Peter; Samali, Afshin; Doyle, Karen M.; Gorman, Adrienne M. (Elsevier BV, 2006-12-01) -
High-resolution scanning electron microscopy for the analysis of three-dimensional ultrastructure of clots in acute ischemic stroke
Mereuta, Oana Madalina; Fitzgerald, Seán; Christensen, Trace A.; Jaspersen, Adam L.; Dai, Daying; Abbasi, Mehdi; Puttappa, Tejaswini; Kadirvel, Ram; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2020-12-23)Background: Characterization of acute ischemic stroke (AIS) clots has typically focused on two dimensional histological analysis of the thrombus. The three dimensional (3D) architecture and distribution of components ... -
Histological characterization of white clots retrieved by mechanical thrombectomy from acute ischemic stroke patients
Mereuta, Oana Madalina; Fitzgerald, Seán; Douglas, Andy; Rossi, Rosanna; Silva Santos, Andreia M.; Pandit, Abhay; Thornton, John; Rentzos, Alexandros; Tatlisumak, Turgut; Doyle, Karen M. (SAGE Publications, 2019-01-01)Introduction: Advances in mechanical thrombectomy have created the unique opportunity to study the acute ischemic stroke clot material. However, there is a lack of uniformity in the histopathologic characterization of ... -
Histological evaluation of acute ischemic stroke thrombi may indicate the occurrence of vessel wall injury during mechanical thrombectomy
Mereuta, Oana Madalina; Doyle, Karen M. (BMJ Publishing Group, 2021-05-11)Background Several animal studies have demonstrated that mechanical thrombectomy (MT) for acute ischemic stroke (AIS) may cause vessel wall injury (VWI). However, the histological changes in human cerebral arteries following ... -
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations
Staessens, S.; Fitzgerald, Seán; Andersson, T.; Clarencon, F.; Denorme, F.; Gounis, M. J.; Hacke, W.; Liebeskind, D. S.; Szikora, I.; van Es, A. C. G. M.; Brinjikji, W.; Doyle, Karen M.; De Meyer, S. F. (SAGE Publications, 2019-11-03)The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ... -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
Kennedy, Donna; Mnich, Katarzyna; Oommen, Deepu; Chakravarthy, Reka; Almeida-Souza, Leonardo; Krols, Michiel; Saveljeva, Svetlana; Doyle, Karen M.; Gupta, Sanjeev; Timmerman, Vincent; Janssens, Sophie; Gorman, Adrienne M.; Samali, Afshin (Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
Hydroxycinnamic acid amide derivatives of polyamines reverse spermine-induced CNS excitation
Bailey, Desiree; Kirby, Brian P.; Atkinson, Jeffrey; Fixon-Owoo, Solomon; Henman, Martin C.; Shaw, Graham G.; Doyle, Karen M. (Elsevier, 2015-03-28)The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess ...