Browsing by Author "Downing, Tim"
Now showing items 1-10 of 10
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A polynucleotide repeat expansion causing temperature-sensitivity persists in wild irish accessions of arabidopsis thaliana
Tabib, Amanda; Vishwanathan, Sailaja; Seleznev, Andrei; McKeown, Peter C.; Downing, Tim; Dent, Craig; Sanchez-Bermejo, Eduardo; Colling, Luana; Spillane, Charles; Balasubramanian, Sureshkumar (Frontiers Media SA, 2016-08-31)Triplet repeat expansions underlie several human genetic diseases such as Huntington's disease and Friedreich's ataxia. Although such mutations are primarily known from humans, a triplet expansion associated genetic defect ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating MiRNAs
Kelly, Helena; Downing, Tim; Tuite, Nina; Smith, Terry; Kerin, Michael; Dwyer, Róisín M.; Clancy, Eoin; Reddington, Kate; Barry, Thomas (Public Library of Science, 2015-09-10)Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed as biomarkers ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating mirnas
Kelly, Helena; Downing, Tim; Tuite, Nina L.; Smith, Terry J.; Kerin, Michael J.; Dwyer, Róisín M.; Clancy, Eoin; Barry, Thomas; Reddington, Kate (Public Library of Science (PLoS), 2015-09-10)Introduction Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed ... -
Estimation and analysis of gene expression and alternative splicing: perspectives from development and disease
Korir, Paul Kibet (2014-01-30)The development of high-throughput genomics technologies has contributed substantially to the understanding of gene expression regulation. With the growing appreciation of the importance of alternative splicing, quantitative ... -
Evolutionary genomics of epidemic visceral leishmaniasis in the indian subcontinent
Imamura, Hideo; Downing, Tim; Van den Broeck, Frederik; Sanders, Mandy J; Rijal, Suman; Sundar, Shyam; Mannaert, An; Vanaerschot, Manu; Berg, Maya; De Muylder, Géraldine; Dumetz, Franck; Cuypers, Bart; Maes, Ilse; Domagalska, Malgorzata; Decuypere, Saskia; Rai, Keshav; Uranw, Surendra; Bhattarai, Narayan Raj; Khanal, Basudha; Prajapati, Vijay Kumar; Sharma, Smriti; Stark, Olivia; Schönian, Gabriele; De Koning, Harry P; Settimo, Luca; Vanhollebeke, Benoit; Roy, Syamal; Ostyn, Bart; Boelaert, Marleen; Maes, Louis; Berriman, Matthew; Dujardin, Jean-Claude; Cotton, James A (eLife Sciences Organisation, Ltd., 2016-03-22)Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per ... -
leishmania naiffi and leishmania guyanensis reference genomes highlight genome structure and gene evolution in the viannia subgenus
Coughlan, Simone; Taylor, Ali Shirley; Feane, Eoghan; Sanders, Mandy; Schonian, Gabriele; Cotton, James A.; Downing, Tim (The Royal Society, 2018-04-01)The unicellular protozoan parasite Leishmania causes the neglected tropical disease leishmaniasis, affecting 12 million people in 98 countries. In South America, where the Viannia subgenus predominates, so far only L. ... -
Pathogen genomics of methicillin resistant staphylococcus aureus and leishmania
Coughlan, Simone (2017-02-15)Infectious diseases caused by the single-celled eukaryotic parasite Leishmania and the methicillin-resistant Staphylococcus aureus (MRSA) bacterium are major public health problems in many countries. In this thesis, I use ... -
Redeploying β-lactam antibiotics as a novel antivirulence strategy for the treatment of methicillin-resistantstaphylococcus aureusinfections
Waters, Elaine M.; Rudkin, Justine K.; Coughlan, Simone; Clair, Geremy C.; Adkins, Joshua N.; Gore, Suzanna; Xia, Guoqing; Black, Nikki S.; Downing, Tim; O'Neill, Eoghan; Kadioglu, Aras; O'Gara, James P. (Oxford University Press (OUP), 2016-11-14)Innovative approaches to the use of existing antibiotics is an important strategy in efforts to address the escalating antimicrobial resistance crisis. We report a new approach to the treatment of methicillin-resistant ... -
tandem amplification of the staphylococcal cassette chromosome mec element can drive high-level methicillin resistance in methicillin-resistant staphylococcus aureus
Gallagher, Laura A.; Coughlan, Simone; Black, Nikki S.; Lalor, Pierce; Waters, Elaine M.; Wee, Bryan; Watson, Mick; Downing, Tim; Fitzgerald, J. Ross; Fleming, Gerard T. A.; O'Gara, James P. (American Society for Microbiology, 2017-07-17)Hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) strains typically express high-level, homogeneous (HoR) beta-lactam resistance, whereas community-associated MRSA (CA-MRSA) more commonly express ... -
The genome of leishmania adleri from a mammalian host highlights chromosome fission in sauroleishmania
Coughlan, Simone; Mulhair, Peter; Sanders, Mandy; Schonian, Gabriele; Cotton, James A.; Downing, Tim (Springer Nature, 2017-03-03)Control of pathogens arising from humans, livestock and wild animals can be enhanced by genomebased investigation. Phylogenetically classifying and optimal construction of these genomes using short sequence reads are key ...