Browsing by Author "Dockery, Peter"
Now showing items 1-20 of 44
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A detailed appraisal of mesocolic lymphangiology - an immunohistochemical and stereological analysis
Culligan, Kevin; Sehgal, Rishabh; Mulligan, Daniel; Dunne, Colum; Walsh, Stewart; Quondamatteo, Fabio; Dockery, Peter; Coffey, J. Calvin (Wiley-Blackwell, 2014-07-19)Inadequate resection of the adjoining mesentery is associated with adverse outcome for colon cancer. Disruption of the integrity of the mesenteric lymphatic package has been implicated in this, though not proven. Recent ... -
Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia
Holleran, Laurena; Ahmed, Mohamed; Anderson-Schmidt, Heike; McFarland, John; Emsell, Louise; Leemans, Alexander; Scanlon, Cathy; Dockery, Peter; McCarthy, Peter; Barker, Gareth J; McDonald, Colm; Cannon, Dara M. (Springer Nature, 2013-10-22)Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and ... -
Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan (Elsevier, 2018-09-26)Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ... -
Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model
O’Loughlin, Aonghus; Kulkarni, Mangesh; Vaughan, Erin E; Creane, Michael; Liew, Aaron; Dockery, Peter; Pandit, Abhay; O’Brien, Timothy (Springer Nature, 2013-01-01)Introduction: Diabetic foot ulceration is the leading cause of amputation in people with diabetes mellitus. Peripheral vascular disease is present in the majority of patients with diabetic foot ulcers. Despite standard ... -
Autophagosomal iκbα degradation plays a role in the long term control of tumor necrosis factor-α-induced nuclear factor-κb (nf-κb) activity
Colleran, Amy; Ryan, Aideen; O'Gorman, Angela; Mureau, Coralie; Liptrot, Catherine; Dockery, Peter; Fearnhead, Howard; Egan, Laurence J. (American Society for Biochemistry & Molecular Biology (ASBMB), 2011-03-31)Transcription factor NF-kappa B is persistently activated in many chronic inflammatory diseases and cancers. The short term regulation of NF-kappa B is well understood, but little is known about the mechanisms of its long ... -
A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction
Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Stefania; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; O'Neill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke-Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena M.; Wildhirt, Stephen; Duffy, Garry P. (Elsevier, 2019-05-15)The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the ... -
C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis
Conroy, Pauline C.; Saladino, Chiara; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G. (Informa UK Limited, 2012-10-15)Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ... -
Calcium-binding capacity of centrin2 is required for linear poc5 assembly but not for nucleotide excision repair
Dantas, Tiago J.; Daly, Owen M.; Conroy, Pauline C.; Tomas, Martin; Wang, Yifan; Lalor, Pierce; Dockery, Peter; Ferrando-May, Elisa; Morrison, Ciaran G. (Public Library of Science (PLoS), 2013-07-02)Centrosomes, the principal microtubule-organising centres in animal cells, contain centrins, small, conserved calcium-binding proteins unique to eukaryotes. Centrin2 binds to xeroderma pigmentosum group C protein (XPC), ... -
Cell viability in three ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan S. (Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Centrobin controls primary ciliogenesis in vertebrates
Ogungbenro, Yetunde Adesanya; Tena, Teresa Casar; Gaboriau, David; Lalor, Pierce; Dockery, Peter; Philipp, Melanie; Morrison, Ciaran G. (Rockefeller University Press, 2018-02-13)The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNT ROB in hTERT-RPE1 cells and observed an increased ... -
Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity
Daly, Owen M.; Gaboriau, David; Karakaya, Kadin; King, Sinéad; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Krämer, Alwin; Morrison, Ciaran G. (The Company of Biologists, 2016-03-10)Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ... -
Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
Xu, Maojia; Stattin, Eva-Lena; Shaw, Georgina; Heinegård, Dick; Sullivan, Gareth; Wilmut, Ian; Colman, Alan; Önnerfjord, Patrik; Khabut, Areej; Aspberg, Anders; Dockery, Peter; Hardingham, Timothy; Murphy, Mary; Barry, Frank (Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord
Madigan, Nicolas N.; Chen, Bingkun K.; Knight, Andrew M.; Rooney, Gemma E.; Sweeney, Eva; Kinnavane, Lisa; Yaszemski, Michael J.; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S.; Windebank, Anthony J. (Mary Ann Liebert, 2014-08-08)The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as a deconstructed model that allows for control of individual variables and direct observation of their effects on regeneration. ... -
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins
Dantas, Tiago J.; Wang, Yifan; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G. (Rockefeller University Press, 2011-04-11)The principal microtubule-organizing center in animal cells, the centrosome, contains centrin, a small, conserved calcium-binding protein unique to eukaryotes. Several centrin isoforms exist and have been implicated in ... -
Developing and implementing a l-openspim platform using in-air optics and measurement of tissue temperature changes
Oluniran, Gideon (NUI Galway, 2023-10-07)Relative to other microscopy techniques, light sheet fluorescence microscopy is widely accepted due to its ability to provide optical sectioning, higher speed, larger field of view, lesser photobleaching, and physiological ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
Moreira da Silva Santos, Andreia; Kelly, John P.; Dockery, Peter; Doyle, Karen M. (Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ... -
Environmental and genetic risk factors in Autism Spectrum Disorder: a stereological study
Rosati, Silvia (NUI Galway, 2020-07-15)Autism spectrum disorders (ASD), include a group of heterogeneous neurodevelopmental disorders (NDDs) characterized by impaired social interaction, and communication with restricted patterns of behaviour. The aetiology ... -
Functional imaging for regenerative medicine
Leahy, Martin; Thompson, Kerry; Zafar, Haroon; Alexandrov, Sergey; Foley, Mark; O’Flatharta, Cathal; Dockery, Peter (BMC, 2016-04-19)In vivo imaging is a platform technology with the power to put function in its natural structural context. With the drive to translate stem cell therapies into pre-clinical and clinical trials, early selection of the right ...