Browsing by Subject "Degradation"
Now showing items 1-7 of 7
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An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical use
(Elsevier, 2023-01-05)This study developed an enhanced phenomenological model for the predictions of surface-based localised corrosion of magnesium alloys for use in medical applications. The modelling framework extended previous surface-based ... -
Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered PCL/b-TCP materials
(Elsevier, 2015-06-06)Orthopaedic scaffold materials were fabricated from polycaprolactone (PCL) and composite PCL β-tricalcium phosphate (PCL/β-TCP) powders using selective laser sintering (SLS). Incorporating β-TCP particles is ... -
Experimental and computational analysis of the mechanical behavior of poly(lactic-co-glycolic acid) during degradation for medical implant applications
(2016-01-25)Biodegradable polymers such as PLGA have been used in a wide range of biomedical applications due to their hydrolytic degradation and biocompatibility. The mechanical performance of biodegradable polymers during degradation ... -
Interaction of cell culture with composition effects on the mechanical properties of polycaprolactone-hydroxyapatite scaffolds fabricated via selective laser sintering (SLS)
(Elsevier, 2012)In the current study PCL/HA composites were fabricated using SLS as two- and three-dimensional lattice structures and exposed to a cellular component (MC 313 osteoblast-like cells). The main aims were to determine the ... -
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
(Elsevier, 2015-09-02)Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational ... -
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
(Nature Publishing Group, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
(American Chemical Society, 2012-02-12)The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ...