Now showing items 1-6 of 6

    • A novel role for hsmg-1 in stress granule formation 

      Brown, J. A. L.; Roberts, T. L.; Richards, R.; Woods, R.; Birrell, G.; Lim, Y. C.; Ohno, S.; Yamashita, A.; Abraham, R. T.; Gueven, N.; Lavin, M. F. (American Society for Microbiology, 2011-09-12)
      hSMG-1 is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family with established roles in nonsense-mediated decay (NMD) of mRNA containing premature termination codons and in genotoxic stress responses to DNA ...
    • Atr activates the s-m checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset 

      Eykelenboom, John Kenneth; Harte, Emma Christina; Canavan, Lynn; Pastor-Peidro, Ana; Calvo-Asensio, Irene; Llorens-Agost, Marta; Lowndes, Noel Francis (Elsevier BV, 2013-11-01)
      Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent ...
    • Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach 

      Wu, Kevin Z. L.; Wang, Guan-Nan; Fitzgerald, Jennifer; Quachthithu, Huong; Rainey, Michael D.; Cattaneo, Angela; Bachi, Angela; Santocanale, Corrado (Oxford University Press (OUP), 2016-07-12)
      In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ...
    • Mechanisms of action of a dual cdc7/cdk9 kinase inhibitor against quiescent and proliferating cll cells 

      Natoni, A.; Murillo, L. S.; Kliszczak, A. E.; Catherwood, M. A.; Montagnoli, A.; Samali, A.; O'Dwyer, M.; Santocanale, C. (American Association for Cancer Research (AACR), 2011-07-18)
      In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism ...
    • Proteomics analysis with a nano random forest approach reveals novel functional interactions regulated by smc complexes on mitotic chromosomes 

      Ohta, Shinya; Montaño-Gutierrez, Luis F.; de Lima Alves, Flavia; Ogawa, Hiromi; Toramoto, Iyo; Sato, Nobuko; Morrison, Ciaran G.; Takeda, Shunichi; Hudson, Damien F.; Rappsilber, Juri; Earnshaw, William C. (American Society for Biochemistry & Molecular Biology (ASBMB), 2016-05-26)
      Packaging of DNA into condensed chromosomes during mitosis is essential for the faithful segregation of the genome into daughter nuclei. Although the structure and composition of mitotic chromosomes have been studied for ...
    • Trinucleotide repeat expansions catalyzed by human cell-free extracts 

      Stevens, Jennifer R; Lahue, Elaine E; Li, Guo-Min; Lahue, Robert S (Springer Nature, 2013-01-22)
      Trinucleotide repeat expansions cause 17 heritable human neurological disorders. In some diseases, somatic expansions occur in non-proliferating tissues such as brain where DNA replication is limited. This finding stimulated ...