Browsing by Subject "DNA-polymerase-eta"
Now showing items 1-2 of 2
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C-jun n-terminal kinase-mediated rad18 phosphorylation facilitates pol recruitment to stalled replication forks
(American Society for Cell Biology (ASCB), 2012-03-28)The E3 ubiquitin ligase Rad18 chaperones DNA polymerase eta (Pol eta) to sites of UV-induced DNA damage and monoubiquitinates proliferating cell nuclear antigen (PCNA), facilitating engagement of Pol eta with stalled ... -
The rad30 cancer susceptibility gene
(Portland Press Ltd., 2003-02-01)The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in RAD30, which encodes the novel lesion bypass DNA polymerase eta. XPV cells are characterized by delayed completion of DNA ...