Browsing by Subject "DNA damage response"
Now showing items 1-20 of 29
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Activation of dna damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation
(Informa UK Limited, 2011-11-01)DNA damaging agents are widely used in treatment of hematogical malignancies and solid tumors. While effects on hematopoietic stem cells have been characterized, less is known about the DNA damage response in human mesenchymal ... -
C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis
(Informa UK Limited, 2012-10-15)Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ... -
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage
(Wiley, 2013-08-02)The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication ... -
Centriolar and ciliary responses to DNA damage
(2012-09-26)Centrosome duplication is tightly controlled and takes place only once every cell cycle. In recent years more light has been shed on the mechanism of centrosome duplication, with key players being identified and characterised. ... -
Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity
(The Company of Biologists, 2016-03-10)Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ... -
Characterisation of novel Histone H3 RAD9 mutants defective in the DNA damage response in Saccharomyces cerevisiae
(2013-02-28)The DNA damage response (DDR) is a signal transduction cascade, which regulates cell cycle progression, gene transcription and DNA repair. Histones also play a vital role in the activation of the DDR and have been shown ... -
Deciphering the role of human MSL2 and MSL1 within and beyond the MSL complex
(2018-01-14)While the components of the MSL (Male Specific Lethal) complex in Drosophila are well studied and known to play a critical role in dosage compensation, there is little known about the function of its evolutionary conserved ... -
Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
(Frontiers Media SA, 2017-04-13)Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic ... -
Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks
(Frontiers Media SA, 2018-06-11)For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ... -
Dna damage induces chk1-dependent threonine-160 phosphorylation and activation of cdk2
(Springer Nature, 2009-10-19)Abnormal centrosome numbers arise in tumours and can cause multipolar mitoses and genome instability. Cdk2 controls normal centrosome duplication, but Chk1-dependent centrosome amplification also occurs after DNA damage. ... -
Doxorubicin induces the dna damage response in cultured human mesenchymal stem cells
(Springer Nature, 2012-10-18)Anthracyclines, including doxorubicin, are widely used in the treatment of leukemia. While the effects of doxorubicin on hematopoietic cells have been characterized, less is known about the response of human mesenchymal ... -
Effects of proteasome inhibition on cisplatin induced DNA damage responses in human cells
(2012-02-07)The proteasome is the main site of protein degradation in human cells, and plays a major role in the regulation of cellular processes including cell cycle progression, DNA repair and the DNA damage response. Proteasome ... -
Functional Analysis of Vertebrate Msl2
(2014-02-12)hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ... -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
(Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Implications of histone H2AX abundance in breast cancer
(NUI Galway, 2019-12-09)Histones are responsible for the packaging of DNA into a eukaryotic cell nucleus, and the H2A variant H2AX plays an important role in the DNA damage response (DDR). The phosphorylated form of H2AX, known as γH2AX, has been ... -
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01) -
The kinesin KIF18B interacts with 53BP1 and is required for efficient double strand break repair
(2015-11-19)Genetic changes can lead to detrimental genomic instability, mutagenesis, oncogenesis and premature aging. The DNA damage response (DDR) is responsible for safeguarding the genome from such harmful alterations. 53BP1 ... -
Mcph1/brit1 limits ionizing radiation-induced centrosome amplification
(Springer Nature, 2010-07-26)Microcephalin (MCPH1/BRIT1) is a potential tumour suppressor that localizes to the centrosome, forms ionizing radiation-induced nuclear foci (IRIF) and is involved in the DNA damage checkpoints that ensure genome stability. ... -
The microprocessing factor DGCR8 interacts with ATM and functions independently of its partner DROSHA in the DDR
(NUI Galway, 2020-01-23)The eukaryotic cell has evolved a complex suite of mechanisms called the DNA damage response (DDR), that acts by sensing DNA damage and reacting appropriately to maintain genomic integrity. The PIK kinase ATM is a key ... -
Mrc1, tof1 and csm3 inhibit cag·ctg repeat instability by at least two mechanisms
(Elsevier BV, 2008-04-01)Trinucleotide repeats frequently expand and contract in humans and model organisms. Protein factors that modulate this process have been found by candidate gene approaches or mutant screens for increased expansion rates. ...