Browsing by Subject "Cycloaddition"
Now showing items 1-5 of 5
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Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis
(Elsevier, 2020-09-18)Synthesis of compounds with characteristics of natural products are required to increase the diversity and biological relevance of compounds for screening. These include new frameworks/scaffolds, with multiple stereogenic ... -
Cycloaddition reactions of imidazolium and phthalazinium dicyanomethanide 1,3-dipoles: synthesis, mechanism and the effect of water
(2017-09-28)The cycloaddition reactions of imidazolium-3-dicyanomethanide 1,3-dipoles with electron poor alkene and alkyne dipolarophiles were explored. The reactions of these azolium 1,3-dipoles with alkyne dipolarophiles generated ... -
A route to 1-Deoxynojirimycin and 1-Deoxymannojirimycin derivatives with quaternary centers adjacent to the ring nitrogen from Methyl α-d-Mannopyranoside
(Wiley, 2020-02-03)6-Alkylated-8-azido-1,6-octadiene derivatives were prepared from methyl α-D-mannopyranoside. The sequence to allylic azide precursors included a Horner-Wadsworth-Emmons reaction with a concomitant epimerization that ... -
Synthesis of Iminosugar C-Glycosides via Tandem Allylic Azide Rearrangement - Huisgen Cycloaddition
(2013-12-16)Iminosugars are naturally occurring polyhydroxylated alkaloids. These natural mimics of carbohydrates have found clinical use with their biological activity mainly attributed to their inhibition of glycoprocessing enzymes. ... -
Synthesis of α-galactosyl ceramide analogues with an α-triazole at the anomeric carbon
(Elsevier, 2014-03-16)The synthesis of 1,2,3-triazole containing analogues of a-GalCer and galacturonic acid containing Sphingomonous cell wall antigens is described. Anomerisation was used to provide the required cc-glycosyl azide precursor. ...