Browsing by Author "Coughlan, Helena"
Now showing items 1-7 of 7
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Comparative genome analysis identifies novel nucleic acid diagnostic targets for use in the specific detection of Haemophilus influenzae
Coughlan, Helena; Reddington, Kate; Tuite, Nina; Wee Boo, Teck; Cormican, Martin; Barrett, Louise; Smith, Terry; Clancy, Eoin; Barry, Thomas (Elsevier, 2015-06-23)Haemophilus influenzae is recognised as an important human pathogen associated with invasive infections, including bloodstream infection and meningitis. Currently used molecular-based diagnostic assays lack specificity in ... -
Comparison of established diagnostic methodologies and a novel bacterial smpB real-time PCR assay for the specific detection of haemophilus influenzae associated with respiratory tract infections
Reddington, Kate; Schwenk, Stefan; Tuite, Nina; Platt, Gareth; Davar, Danesh; Coughlan, Helena; Personne, Yoann; Enne, Virve I.; Zumla, Alimuddin; Barry, Thomas (American Society for Microbiology, 2015-06-23)Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a rapid H. influenzae diagnostic assay that would allow for the implementation of infection control ... -
Comparison of established diagnostic methodologies and a novel bacterialsmpbreal-time pcr assay for specific detection of haemophilus influenzae isolates associated with respiratory tract infections
Reddington, Kate; Schwenk, Stefan; Tuite, Nina; Platt, Gareth; Davar, Danesh; Coughlan, Helena; Personne, Yoann; Gant, Vanya; Enne, Virve I.; Zumla, Alimuddin; Barry, Thomas (American Society for Microbiology, 2015-06-24)Haemophilus influenzae is a significant causative agent of respiratory tract infections (RTI) worldwide. The development of a rapid H. influenzae diagnostic assay that would allow for the implementation of infection control ... -
Development of an on-disc isothermal in vitro amplification and detection of bacterial rna
Brennan, Des; Coughlan, Helena; Clancy, Eoin; Dimov, Nikolay; Barry, Thomas; Kinahan, David; Ducrée, Jens; Smith, Terry J.; Galvin, Paul (Elsevier BV, 2017-02-01) -
Development of novel nucleic acid diagnostics technologies for the detection of predominant microorganisms associated with bacterial meningitis
Coughlan, Helena (2017-01-13)With an estimated 1.2 million cases annually worldwide, bacterial meningitis is a medical emergency and primary prevention as well as accurate diagnosis and treatment of this often fatal disease is paramount. The ... -
Solvent-selective routing for centrifugally automated solid-phase purification of rna
Dimov, Nikolay; Clancy, Eoin; Gaughran, Jennifer; Boyle, David; Mc Auley, Darren; Glynn, Macdara T.; Dwyer, Róisín M.; Coughlan, Helena; Barry, Thomas; Barrett, Louise M.; Smith, Terry J.; Ducrée, Jens (Springer Nature, 2014-09-12)We present a disc-based module for rotationally controlled solid-phase purification of RNA from cell lysate. To this end, multi-stage routing of a sequence of aqueous and organic liquids into designated waste and elution ... -
Solvent-selective routing for centrifugally automated solid-phase purification of RNA.
Clancy, Eoin; Coughlan, Helena; Helena, Thomas; Smith, Terry; Dwyer, Róisín M. (Springer, 2014-09-12)We present a disc-based module for rotationally controlled solid-phase purification of RNA from cell lysate. To this end, multi-stage routing of a sequence of aqueous and organic liquids into designated waste and elution ...