Browsing by Subject "Chondrocyte"
Now showing items 1-6 of 6
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Allogeneic cell therapy for osteoarthritis
(2016-05-11)Osteoarthritis is a debilitating multi-factorial joint disease which currently has no cure. Due to the significant immune cell mediated component in this disease a therapy which can modulate this inflammation and promote ... -
Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading
(Elsevier, 2012-12-24)Previous experimental studies have determined local strain fields for both healthy and degenerate cartilage tissue during mechanical loading. However, the biomechanical response of chondrocytes in situ, in particular the ... -
The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation
(The Royal Society Publishing, 2012-07-18)The biomechanisms that govern the response of chondrocytes to mechanical stimuli are poorly understood. In this study, a series of in vitro tests are performed, in which single chondrocytes are subjected to shear deformation ... -
Evaluation of human induced pluripotent stem cell-based cellular models for pathological investigation of genetic skeletal diseases
(NUI Galway, 2019-02-15)The uniqueness of stem cells endows them with the capacity to be used as a valuable tool in the field of pathology, particularly the one from patients. Patient-specific cellular model can be generated by deriving donor-specific ... -
The Role of the Actin Cytoskeleton in the Response of Chondrocytes to Mechanical Loading: A Computational and Experimental Investigation
(2012-09-28)The biomechanisms which govern the response of chondrocytes to mechanical stimuli are poorly understood. This thesis aims to provide a more in depth understanding of chondrocyte biomechanics by focusing on the role of actin ... -
Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
(The Royal Society Publishing, 2012-06-06)The osteocyte is believed to act as the main sensor of mechanical stimulus in bone, controlling signalling for bone growth and resorption in response to changes in the mechanical demands placed on our bones throughout life. ...