Browsing by Subject "Centrosome"

Now showing items 1-8 of 8

    • Centriolar and ciliary responses to DNA damage 

      Conroy, Pauline Ciara (2012-09-26)
      Centrosome duplication is tightly controlled and takes place only once every cell cycle. In recent years more light has been shed on the mechanism of centrosome duplication, with key players being identified and characterised. ...

    • Centrobin functions in centriole duplication, primary ciliogenesis and genome maintenance 

      Adesanya, Yetunde (2018-03-06)
      The centrosome is composed of numerous proteins that make up its core structure. Other proteins also transiently localise and interact with centrosomal proteins for functional modulation. Centrobin, one of the core centrosomal ...

    • Centrosome cohesion: functions of C-NAP1 

      Flanagan, Anne-Marie (2016-01-07)
      Double stranded DNA encodes the genetic material of the cell. Replication and segregation cycles are regulated in order to maintain the integrity of the DNA sequence from one cell cycle to the next. Detection of lesions ...

    • An investigation of the contribution of centrosomal genes to schizophrenia and cognitive function 

      Flynn, Mairéad (NUI Galway, 2020-03-11)
      The centrosome is the key microtubule organising centre of animal somatic cells. Centrosomes play a crucial role in brain development, influencing cell shape, polarity, motility, and division. The older of the two barrel-shaped ...

    • Reverse genetic analysis of centrosomal roles of Checkpoint Kinase 1 

      Basavaraju, Shivakumar (NUI Galway, 2019-06-14)
      Centrosome duplication is tightly regulated process that occurs only once per cell cycle. Centrosome abnormalities have been observed in cancer cells and in cells with defective DNA damage responses. Genotoxic stresses ...

    • Reverse Genetic Analysis of Pericentrin Functions 

      Wang, Yifan Jr (2012-06-11)
      The centrosome is a subcellular organelle that organises the mitotic spindle microtubules to ensure accurate segregation of chromosomes during cell division. Most animal centrosomes comprise a pair of centrioles which are ...

    • The roles of centrins/caltractins at the centrosome and in genome maintenance 

      Dantas, Tiago Jorge O.G. de Almeida (2012-06-21)
      The principal microtubule-organising centre in animal cells, the centrosome, contains centrin, a small, highly-conserved calcium-binding protein that can be found throughout eukaryotes. Several centrin isoforms exist and ...

    • Understanding the multifunctional domains of controller protein Centrin2 

      Khouj, Ebtissal (NUI Galway, 2018-12-21)
      Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics and ciliogenesis. Structurally, it has four calcium-binding EF- hand motifs. Most of the cellular centrin2 is not associated ...