Browsing by Author "Carew, J. S."

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    • Inhibition of nedd8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia 

      Swords, R. T.; Kelly, K. R.; Smith, P. G.; Garnsey, J. J.; Mahalingam, D.; Medina, E.; Oberheu, K.; Padmanabhan, S.; O'Dwyer, M.; Nawrocki, S. T.; Giles, F. J.; Carew, J. S. (American Society of Hematology, 2010-03-04)
      NEDD8 activating enzyme (NAE) has been identified as an essential regulator of the NEDD8 conjugation pathway, which controls the degradation of many proteins with important roles in cell-cycle progression, DNA damage, and ...