Now showing items 1-5 of 5

  • Advances in precision medicine: tailoring individualized therapies 

    Matchett, Kyle; Lynam-Lennon, Niamh; Watson, R.; Brown, James (MDPI AG, 2017-10-25)
    The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately ...
  • Circulating nucleosomes and nucleosome modifications as biomarkers in cancer 

    McAnena, Peter; Brown, James; Kerin, Michael (MDPI AG, 2017-01-08)
    Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict ...
  • Clinically applicable inhibitors impacting genome stability 

    Prakash, Anu; Garcia-Moreno, Juan; Brown, James; Bourke, Emer (MDPI AG, 2018-05-13)
    Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize ...
  • Effects of age on the detection and management of breast cancer 

    McGuire, Andrew; Brown, James; Malone, Carmel; McLaughlin, Ray; Kerin, Michael (MDPI AG, 2015-05-22)
    Currently, breast cancer affects approximately 12% of women worldwide. While the incidence of breast cancer rises with age, a younger age at diagnosis is linked to increased mortality. We discuss age related factors affecting ...
  • Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer 

    Casey, Máire-Caitlín (2016-11-25)
    Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ...