Browsing by Author "Birmingham, Evelyn"
Now showing items 1-3 of 3
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The mechanical environment of the stem cell niche in bone marrow
Birmingham, Evelyn (2014-06-13)Understanding how bone marrow mesenchymal stem cells (MSCs) contribute to new bone formation and remodelling in vivo is of principal importance for informing the development of effective bone tissue engineering strategies ... -
Mechanical stimulation of bone marrow in situ induces bone formation in trabecular explants
Birmingham, Evelyn; Kreipke, T. C.; Dolan, E.B.; Coughlin, T.R.; Owens, Peter; McNamara, Laoise M.; Niebur, G.L.; McHugh, Peter E. (Springer Verlag, 2014-10-04)Abstract Low magnitude high frequency (LMHF) loading has been shown to have an anabolic effect on trabecular bone in vivo. However, the precise mechanical signal imposed on the bone marrow cells by LMHF loading, which ... -
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone niche
Birmingham, Evelyn; Niebur, G.L.; McHugh, Peter E.; Shaw, G.; Barry, F.P.; McNamara, Laoise M. (AO Research Institute Davos, 2012)Mesenchymal stem cells (MSCs) within their native environment of the stem cell niche in bone receive biochemical stimuli from surrounding cells. These stimuli likely influence how MSCs differentiate to become bone precursors. ...