Browsing by Subject "Biomaterials"
Now showing items 1-20 of 20
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Biomaterial scaffolds and genetically modified stem cells - An Investigation of their potential in bone repair
(2017-10-10)The task of repairing large sections of bone tissue lost due to major trauma or pathology poses a significant challenge in orthopedic healthcare. The medical intervention often resorted to consists of a combination of ... -
A Biomaterials Approach for an Ex-Vivo Multiple Sclerosis Model of Inflammatory Demyelination
(2013-10-03)Multiple sclerosis (MS) is characterised by the presence of inflammatory demyelinating foci throughout the brain and spinal cord, accompanied by axonal and neuronal damage. Although inflammatory processes are thought to ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
(2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Development of novel biomaterials and medical devices to improve diabetes treatment and ambient cell transportation
(NUI Galway, 2023-02-08)Diabetes mellitus is a global pandemic affecting to more than 500 million people worldwide, with Type 1 diabetics being the most at risk due to life-threatening hyper and hypoglycaemic complications. Islet transplantation ... -
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair
(Elsevier, 2012-06-25)The current microsurgical gold standard for repairing long gap nerve injuries is the autograft. Autograft provides a protective environment for repair and a natural internal architecture, which is essential for regeneration. ... -
Effect of surface chemistry on islet amyloid polypeptide conformation
(American Institute of Physics, 2020-09-04)The formation of dense, linear arrays (fibrils) by biomolecules is the hallmark of a number of degenerative diseases, such as Alzheimer s and type-2 diabetes. Protein fibrils have also attracted interest as building blocks ... -
Elastin-based hydrogel as a treatment for critical limb ischemia, an insight into the glyco-host response
(NUI Galway, 2019-10-01)Critical limb ischemia (CLI) is severe impairment of the microcirculation resulting in inflammation, ischaemic pain, non-healing ulcers and gangrene. Over 20% of patients have no option but to undergo a major limb amputation. ... -
Fibrin-in-fibrin intervention for enhanced dopaminergic graft survival in Parkinson’s disease: Special focus on brain N-glycans
(NUI Galway, 2019-11-07)Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder caused due to the selective loss of dopaminergic neurons in substantia nigra pars compacta (SN) translating into the classical motor symptoms ... -
A glyco approach for the treatment of Parkinson’s disease: From the glycobiological characterisation to the development of glyco-modulatory collagen-based hydrogel systems
(NUI Galway, 2021-12-20)Parkinson’s disease (PD) is the most common motor-related progressive neurodegenerative condition, mainly caused by the loss of dopaminergic neurons in the substantia nigra. Despite the increased knowledge regarding its ... -
Integrated proteomic and systems biology approach to understanding injured spinal cord pathophysiology and repair
(NUI Galway, 2020-03-05)Spinal cord injury (SCI) is a severe neurological condition. There are currently no effective treatment options to restore function following SCI. The major obstacle to developing effective therapies is the fragmented ... -
Interface waves in misoriented pre-stressed incompressible elastic solids
(Oxford Journals, 2004-12-17)Some relationships, fundamental to the resolution of interface wave problems, are presented. These equations allow for the derivation of explicit secular equations for problems involving waves localized near the plane ... -
A multi-modal collagen nucleic acid delivery system for the modulation of inflammation and promotion of angiogenesis
(2014-12-15)Tissue engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue engineered constructs, ... -
The natural adhesive of the goose barnacle Lepas anatifera: The functional morphology and chemistry of the adhesive gland and an investigation of the adhesive proteins
(2013-12-25)The adhesive and adhesive glands of the stalked barnacle Lepas anatifera were investigated using a wide range of techniques to characterise them and compare them to distantly related acorn barnacles, as well as other ... -
Novel Cell-Based Therapies for the Treatment of Diabetic Ulceration
(2012-02-28)The focus of this research is on developing novel cell based therapies for the treatment of non-healing diabetic foot ulceration. The thesis begins with a concise review of the diabetic foot ulcers. The burden associated ... -
Optimisation and characterisation of cholecyst-derived extracellular matrix for abdominal wall reconstruction
(NUI Galway, 2018-10-19)Polypropylene mesh was created by Usher in 1962 after he experienced unsatisfactory results from using autografts and allografts for hernia repairs. More than fifty years later, polypropylene is still the most popular ... -
The past, present and future in scaffold-based tendon treatments
(Elsevier, 2015-04)Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young ... -
The potential of GDF5-functionalised collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2020-03-05)Parkinson’s disease is a progressive neurodegenerative disorder associated with the loss of dopaminergic neurons from the substantia nigra and striatum. Over time, the gold standard pharmacotherapy, L-dopa, loses its ... -
The potential of injectable collagen hydrogels to enhance dopaminergic cell replacement therapies for Parkinson's disease
(NUI Galway, 2018-10-04)Extensive pre-clinical and clinical assessment has shown that, when transplanted into the Parkinsonian brain, primary dopaminergic neurons can survive, integrate with the host system, produce dopamine and provide functional ... -
Quantum dots in bio-imaging and drug delivery
(2015-11-23)This work explores a range of bionanomaterials, with particular attention to their influence on cell growth, function and fate. Also the issue of intracellular nanoparticles quantification has been addressed in experimental ... -
Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks
(Nature Publishing Group, 2017-10-13)Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these ...