Browsing by Subject "Angiogenesis"
Now showing items 1-10 of 10
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Biological characterization of a human mesenchymal stromal cell product
(2016-07-21)The translation of stem cell research into a therapeutic setting presents with it many scientific, logistic, financial and regulatory challenges for academic scientists. This thesis identifies some key areas that one must ... -
Development of a microgel-based cell delivery platform for critical limb ischemia
(2017-05-05)Peripheral Arterial Diseases (PAD) is a chronic and debilitating disease caused due to narrowing and hardening of arteries, that results in progressive deterioration of blood flow to the limbs. PAD commonly occurs in the ... -
Elastin-like polypeptide mediated proangiogenic and anti-inflammatory gene therapy for critical limb ischemia
(2014-12-17)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been modest success in reducing the rate of amputations in these patients. Reduced level of blood flow and enhanced inflammation ... -
Extracellular vesicles as modulators of wound healing
(Elsevier, 2018-01-31)Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ... -
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
(Springer, 2011-02-23)Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ... -
An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia
(Elsevier, 2015-10)Critical limb ischemia is a major clinical problem. Despite rigorous treatment regimes, there has been only modest success in reducing the rate of amputations in affected patients. Reduced level of blood flow and enhanced ... -
Local pharmacological induction of angiogenesis: drugs for cells and cells as drugs
(Elsevier, 2019-06-19)The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major ... -
A multi-modal collagen nucleic acid delivery system for the modulation of inflammation and promotion of angiogenesis
(2014-12-15)Tissue engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue engineered constructs, ... -
Non-viral gene therapy for myocardial engineering
(John Wiley & Sons, Ltd., 2010-05)Despite significant advances in surgical and pharmacological techniques, myocardial infarction (MI) remains the main cause of morbidity in the developed world because no remedy has been found for the regeneration of infarcted ... -
Vascular plasticity and target for therapy in Duchenne muscular dystrophy
(NUI Galway, 2023-06-13)Angiogenesis is the growth of new blood vessels from pre-existing vessels, necessary for the growth and maintenance of homeostasis. Duchenne muscular dystrophy (DMD) is a debilitating disease of the musculoskeletal ...