Browsing by Author "Almotairy, Awatif Rashed Z."
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Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid
Almotairy, Awatif Rashed Z.; Gandin, Valentina; Morrison, Liam; Marzano, Cristina; Montagner, Diego; Erxleben, Andrea (Elsevier, 2017-09-10)Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by 1H and 195Pt NMR spectroscopy, electrospray ... -
Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid
Tolan, Dina; Almotairy, Awatif Rashed Z.; Howe, Orla; Devereux, Michael; Montagner, Diego; Erxleben, Andrea (Elsevier, 2019-04-19)The coordination of biologically active moieties to the axial positions of Pt(IV) derivatives of Pt(II) anticancer drugs allows the co-delivery and simultaneous activation of two pro-drugs for combination therapy. Pt(IV) ...