Browsing by Subject "ttrap"
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Tdp2 protects transcription from abortive topoisomerase activity and is required for normal neural function
(Springer Nature, 2014-03-23)Topoisomerase II (TOP2) removes torsional stress from DNA and facilitates gene transcription by introducing transient DNA double-strand breaks (DSBs). Such DSBs are normally rejoined by TOP2 but on occasion can become ...