Now showing items 1-1 of 1

    • A dileucine in the protease of botulinum toxin a underlies its long-lived neuroparalysis 

      Wang, Jiafu; Zurawski, Tomas H.; Meng, Jianghui; Lawrence, Gary; Olango, Weredeselam M.; Finn, David P.; Wheeler, Larry; Dolly, J. Oliver (American Society for Biochemistry & Molecular Biology (ASBMB), 2010-12-07)
      Blockade of neurotransmitter release by botulinum neurotoxin type A (BoNT(A)) underlies the severe neuroparalytic symptoms of human botulism, which can last a few years. The structural basis for this remarkable persistence ...