Now showing items 1-3 of 3

    • Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated disrupted-in-schizophrenia 1 

      Dawson, N; Kurihara, M; Thomson, D M; Winchester, C L; McVie, A; Hedde, J R; Randall, A D; Shen, S; Seymour, P A; Hughes, Z A; Dunlop, J; Brown, J T; Brandon, N J; Morris, B J; Pratt, J A (Springer Nature, 2015-05-19)
      Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain ...
    • Intracellular mechanisms underlying the nicotinic enhancement of ltp in the rat dentate gyrus 

      Welsby, Philip J.; Rowan, Michael J.; Anwyl, Roger (Wiley-Blackwell, 2009-01-01)
      We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of alpha 7 nAChR. In the present studies, ...
    • Verbal working memory and functional large-scale networks in schizophrenia 

      Dauvermann, Maria R.; Moorhead, Thomas WJ; Watson, Andrew R.; Duff, Barbara; Romaniuk, Liana; Hall, Jeremy; Roberts, Neil; Lee, Graham L.; Hughes, Zoë A.; Brandon, Nicholas J.; Whitcher, Brandon; Blackwood, Douglas HR; McIntosh, Andrew M.; Lawrie, Stephen M. (Elsevier BV, 2017-12-01)
      The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between patients with schizophrenia (SZ) and healthy controls (HC). We ...