Browsing by Subject "protein-kinase"
Now showing items 1-7 of 7
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A novel role for hsmg-1 in stress granule formation
(American Society for Microbiology, 2011-09-12)hSMG-1 is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family with established roles in nonsense-mediated decay (NMD) of mRNA containing premature termination codons and in genotoxic stress responses to DNA ... -
C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis
(Informa UK Limited, 2012-10-15)Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ... -
Ddk dependent regulation of top2a at centromeres revealed by a chemical genetics approach
(Oxford University Press (OUP), 2016-07-12)In eukaryotic cells the CDC7/DBF4 kinase, also known as DBF4-dependent kinase (DDK), is required for the firing of DNA replication origins. CDC7 is also involved in replication stress responses and its depletion sensitises ... -
Dna-pk activity is associated with caspase-dependent myogenic differentiation
(Wiley-Blackwell, 2016-10-01)Differentiation of myoblasts into myotubes is essential for skeletal muscle development and regeneration. Caspase-3 and caspase-9 are required for efficient myoblast differentiation. The caspase-activated endonuclease ... -
Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis
(Rockefeller University Press, 2015-05-11)Nek5 is a poorly characterized member of the NIMA-related kinase family, other members of which play roles in cell cycle progression and primary cilia function. Here, we show that Nek5, similar to Nek2, localizes to the ... -
Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia
(Elsevier BV, 2014-09-01) -
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia
(American Association for Cancer Research (AACR), 2009-10-13)Pyrrolo-1,5-benzoxazepine-15 (PBOX-15) is a novel microtubule depolymerization agent that induces cell cycle arrest and subsequent apoptosis in a number of cancer cell lines. Chronic lymphocytic leukemia (CLL) is characterized ...