Browsing by Subject "microrna"
Now showing items 1-11 of 11
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A circulating microrna signature as a biomarker for prostate cancer in a high risk group
(MDPI AG, 2015-07-07)Introduction: Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs ... -
Circulating nucleosomes and nucleosome modifications as biomarkers in cancer
(MDPI AG, 2017-01-08)Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict ... -
Combining evidence of preferential gene-tissue relationships from multiple sources
(Public Library of Science (PLoS), 2013-08-12)An important challenge in drug discovery and disease prognosis is to predict genes that are preferentially expressed in one or a few tissues, i.e. showing a considerably higher expression in one tissue(s) compared to the ... -
Engineering exosomes for cancer therapy
(MDPI AG, 2017-05-24)There remains an urgent need for novel therapeutic strategies to treat metastatic cancer, which results in over 8 million deaths annually worldwide. Following secretion, exosomes are naturally taken up by cells, and capable ... -
Evolution of a research field—a micro (rna) example
(PeerJ, 2015-03-17)Background. Every new scientific field can be traced back to a single, seminal publication. Therefore, a bibliometric analysis can yield significant insights into the history and potential future of a research field. This ... -
Genome-wide identification of novel micrornas and their target genes in the human parasite schistosoma mansoni
(Elsevier BV, 2011-08-01) -
Genome-wide microrna binding site variation between extinct wild aurochs and modern cattle identifies candidate microrna-regulated domestication genes
(Frontiers Media SA, 2017-01-31)The domestication of cattle from the now-extinct wild aurochs (Bos primigenius) involved selection for physiological and behavioral traits, with underlying genetic factors that remain largely unknown. Non coding microRNAs ... -
Genome-wide schizophrenia variant at mir137 does not impact white matter microstructure in healthy participants
(Elsevier BV, 2014-06-01) -
Microrna-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced dna damage response through cdc7 kinase in lung cancer cells
(Springer Nature, 2013-07-01)Cdc7 kinase is a key regulator of DNA replication and has an important role in the cellular DNA damage response by controlling checkpoint signaling and cell survival. Yet, how the activity of Cdc7 kinase is regulated is ... -
Micrornas in colorectal cancer: function, dysregulation and potential as novel biomarkers
(Elsevier BV, 2011-08-01) -
Perk regulated mir-424(322)-503 cluster fine-tunes activation of ire1 and atf6 during unfolded protein response
(Springer Nature, 2015-12-17)The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...