Now showing items 1-2 of 2

    • A collagen-based scaffold delivering exogenous microrna-29b to modulate extracellular matrix remodeling 

      Monaghan, Michael; Browne, Shane; Schenke-Layland, Katja; Pandit, Abhay (Elsevier BV, 2014-04-01)
      Directing appropriate extracellular matrix remodeling is a key aim of regenerative medicine strategies. Thus, antifibrotic interfering RNA (RNAi) therapy with exogenous microRNA (miR)-29B was proposed as a method to modulate ...
    • Pravastatin reduces marfan aortic dilation 

      McLoughlin, D.; McGuinness, J.; Byrne, J.; Terzo, E.; Huuskonen, V.; McAllister, H.; Black, A.; Kearney, S.; Kay, E.; Hill, A. D. K.; Dietz, H. C.; Redmond, J. M. (Ovid Technologies (Wolters Kluwer Health), 2011-09-12)
      Background-The sequelae of aortic root dilation are the lethal consequences of Marfan syndrome. The root dilation is attributable to an imbalance between deposition of matrix elements and metalloproteinases in the aortic ...