Browsing by Subject "human-cells"
Now showing items 1-9 of 9
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Calcium-binding capacity of centrin2 is required for linear poc5 assembly but not for nucleotide excision repair
(Public Library of Science (PLoS), 2013-07-02)Centrosomes, the principal microtubule-organising centres in animal cells, contain centrins, small, conserved calcium-binding proteins unique to eukaryotes. Centrin2 binds to xeroderma pigmentosum group C protein (XPC), ... -
Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification
(American Society for Cell Biology (ASCB), 2017-01-18)Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ... -
Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
(Informa UK Limited, 2014-09-02)Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers ... -
Hucop1 contributes to the regulation of dna repair in keratinocytes
(Springer Nature, 2016-12-19)We have previously demonstrated that the E3 ligase Human Constitutive Photomorphogenic Protein (huCOP1) is expressed in human keratinocytes and negatively regulates p53. The MutS homolog 2 (MSH2) protein plays a central ... -
Integrating the genomic architecture of human nucleolar organizer regions with the biophysical properties of nucleoli
(Wiley-Blackwell, 2017-06-02)Nucleoli are the sites of ribosome biogenesis and the largest membraneless subnuclear structures. They are intimately linked with growth and proliferation control and function as sensors of cellular stress. Nucleoli form ... -
Requirement for plk1 kinase activity in the maintenance of a robust spindle assembly checkpoint
(The Company of Biologists, 2015-12-18)During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ... -
The 26s proteasome drives trinucleotide repeat expansions
(Oxford University Press (OUP), 2013-04-24)Trinucleotide repeat (TNR) expansion is the causative mutation for at least 17 inherited neurological diseases. An important question in the field is which proteins drive the expansion process. This study reports that the ... -
The cenp-t/-w complex is a binding partner of the histone chaperone fact
(Cold Spring Harbor Laboratory, 2016-06-01)The CENP-T/-W histone fold complex, as an integral part of the inner kinetochore, is essential for building a proper kinetochore at the centromere in order to direct chromosome segregation during mitosis. Notably, CENP-T/-W ... -
The nse2/mms21 sumo ligase of the smc5/6 complex in the maintenance of genome stability
(Wiley-Blackwell, 2011-05-04)