Browsing by Subject "duplication"

Now showing items 1-9 of 9

    • C-nap1 and rootletin restrain dna damage-induced centriole splitting and facilitate ciliogenesis 

      Conroy, Pauline C.; Saladino, Chiara; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Morrison, Ciaran G. (Informa UK Limited, 2012-10-15)
      Cilia are found on most human cells and exist as motile cilia or non-motile primary cilia. Primary cilia play sensory roles in transducing various extracellular signals, and defective ciliary functions are involved in a ...

    • Centrin2 regulates cp110 removal in primary cilium formation 

      Prosser, Suzanna L.; Morrison, Ciaran G. (Rockefeller University Press, 2015-03-09)
      Primary cilia are antenna-like sensory microtubule structures that extend from basal bodies, plasma membrane-docked mother centrioles. Cellular quiescence potentiates ciliogenesis, but the regulation of basal body formation ...

    • Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification 

      Flanagan, Anne-Marie; Stavenschi, Elena; Basavaraju, Shivakumar; Gaboriau, David; Hoey, David A.; Morrison, Ciaran G. (American Society for Cell Biology (ASCB), 2017-01-18)
      Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ...

    • Centrosome amplification in cho and dt40 cells by inactivation of cyclin-dependent kinases 

      Steere, Nathan; Wagner, Michael; Beishir, Stephen; Smith, Ewan; Breslin, Loretta; Morrison, Ciaran G.; Hochegger, Helfrid; Kuriyama, Ryoko (Wiley-Blackwell, 2011-07-29)

    • Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity 

      Breslin, Loretta; Prosser, Suzanna L; Cuffe, Sandra; Morrison, Ciaran G (Informa UK Limited, 2014-09-02)
      Somatic cells senesce in culture after a finite number of divisions indefinitely arresting their proliferation. DNA damage and senescence increase the cellular number of centrosomes, the 2 microtubule organizing centers ...

    • Dna damage induces chk1-dependent threonine-160 phosphorylation and activation of cdk2 

      Bourke, E; Brown, J A L; Takeda, S; Hochegger, H; Morrison, C G (Springer Nature, 2009-10-19)
      Abnormal centrosome numbers arise in tumours and can cause multipolar mitoses and genome instability. Cdk2 controls normal centrosome duplication, but Chk1-dependent centrosome amplification also occurs after DNA damage. ...

    • Loss of centrioles causes chromosomal instability in vertebrate somatic cells 

      Sir, Joo-Hee; Pütz, Monika; Daly, Owen; Morrison, Ciaran G.; Dunning, Mark; Kilmartin, John V.; Gergely, Fanni (Rockefeller University Press, 2013-12-02)
      Most animal cells contain a centrosome, which comprises a pair of centrioles surrounded by an ordered pericentriolar matrix (PCM). Although the role of this organelle in organizing the mitotic spindle poles is well ...

    • Phylotastic! making tree-of-life knowledge accessible, reusable and convenient 

      Stoltzfus, Arlin; Lapp, Hilmar; Matasci, Naim; Deus, Helena; Sidlauskas, Brian; Zmasek, Christian M; Vaidya, Gaurav; Pontelli, Enrico; Cranston, Karen; Vos, Rutger; Webb, Campbell O; Harmon, Luke J; Pirrung, Megan; O'Meara, Brian; Pennell, Matthew W; Mirarab, Siavash; Rosenberg, Michael S; Balhoff, James P; Bik, Holly M; Heath, Tracy A; Midford, Peter E; Brown, Joseph W; McTavish, Emily Jane; Sukumaran, Jeet; Westneat, Mark; Alfaro, Michael E; Steele, Aaron; Jordan, Greg (Springer Nature, 2013-01-01)
      Background: Scientists rarely reuse expert knowledge of phylogeny, in spite of years of effort to assemble a great "Tree of Life" (ToL). A notable exception involves the use of Phylomatic, which provides ...

    • The emerging biofuel crop camelina sativa retains a highly undifferentiated hexaploid genome structure 

      Kagale, Sateesh; Koh, Chushin; Nixon, John; Bollina, Venkatesh; Clarke, Wayne E.; Tuteja, Reetu; Spillane, Charles; Robinson, Stephen J.; Links, Matthew G.; Clarke, Carling; Higgins, Erin E.; Huebert, Terry; Sharpe, Andrew G.; Parkin, Isobel A. P. (Springer Nature, 2014-04-23)
      Camelina sativa is an oilseed with desirable agronomic and oil-quality attributes for a viable industrial oil platform crop. Here we generate the first chromosome-scale high-quality reference genome sequence for C. sativa ...