Browsing by Subject "cyclin-e overexpression"
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Dna damage induces chk1-dependent threonine-160 phosphorylation and activation of cdk2
(Springer Nature, 2009-10-19)Abnormal centrosome numbers arise in tumours and can cause multipolar mitoses and genome instability. Cdk2 controls normal centrosome duplication, but Chk1-dependent centrosome amplification also occurs after DNA damage. ...