Browsing by Subject "c-myc"
Now showing items 1-4 of 4
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Allele-specific transcriptional elongation regulates monoallelic expression of the igf2bp1 gene
(Springer Nature, 2011-01-01)Background: Random monoallelic expression contributes to phenotypic variation of cells and organisms. However, the epigenetic mechanisms by which individual alleles are randomly selected for expression are not known. Taking ... -
An integrated genome screen identifies the wnt signaling pathway as a major target of wt1
(Proceedings of the National Academy of Sciences, 2009-06-22)WT1, a critical regulator of kidney development, is a tumor suppressor for nephroblastoma but in some contexts functions as an oncogene. A limited number of direct transcriptional targets of WT1 have been identified to ... -
Defining the structural origin of the substrate sequence independence of o-glcnacase using a combination of molecular docking and dynamics simulation
(Oxford University Press (OUP), 2013-10-16)Protein glycosylation with O-linked N-acetylglucosamine (O-GlcNAc) is a post-translational modification of serine/threonine residues in nucleocytoplasmic proteins. O-GlcNAc has been shown to play a role in many different ... -
Targeting the pim kinases in multiple myeloma
(Springer Nature, 2015-07-17)Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. Novel treatment strategies to improve survival are urgently required. The Pims are a small family of serine/threonine kinases with increased expression ...