Now showing items 1-20 of 43

    • A germline mutation in the brca13’utr predicts stage iv breast cancer 

      Dorairaj, Jemima J; Salzman, David W; Wall, Deirdre; Rounds, Tiffany; Preskill, Carina; Sullivan, Catherine AW; Lindner, Robert; Curran, Catherine; Lezon-Geyda, Kim; McVeigh, Terri; Harris, Lyndsay; Newell, John; Kerin, Michael J; Wood, Marie; Miller, Nicola; Weidhaas, Joanne B (Springer Nature, 2014-06-10)
      Background: A germline, variant in the BRCA1 3'UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. ...
    • Adipose-derived stem cells in novel approaches to breast reconstruction: their suitability for tissue engineering and oncological safety 

      O'Halloran, Niamh; Courtney, Donald; Kerin, Michael; Lowery, Aoife (SAGE Publications, 2017-08-16)
      Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients ...
    • Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics 

      Kheirelseid, Elrasheid A. H.; Jumustafa, Hanzali; Miller, Nicola; Curran, Catherine; Sweeney, Karl; Malone, Carmel; McLaughlin, Ray; Newell, John; Kerin, Michael J. (Springer Nature, 2010-07-28)
      There has been conflicting evidence on the impact of bilateral breast cancer (BBC) on the survival and management of patients. The objectives of this study were to address the incidence of BBC and to investigate its ...
    • Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options 

      McAnena, Peter F.; Brown, James AL; Ramli, A.; Curran, C.; Malone, C.; McLaughlin, R.; Barry, K.; JAL, Brown; Kerin, M. J. (Springer Nature, 2018-02-20)
      Background: Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ...
    • Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer 

      Ambs, Stefan; Glynn, Sharon A. (Informa UK Limited, 2011-02-15)
      Inducible nitric oxide synthase (NOS2) is an inflammation responsive enzyme (EC 1.14.13.39) that is induced during acute and chronic inflammation and tissue injury as part of the host defense and wound healing process. ...
    • Circulating nucleosomes and nucleosome modifications as biomarkers in cancer 

      McAnena, Peter; Brown, James; Kerin, Michael (MDPI AG, 2017-01-08)
      Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict ...
    • Clinical use of the oncotype dx genomic test to guide treatment decisions for patients with invasive breast cancer 

      McVeigh, Terri P; Kerin, Michael J (Dove Medical Press Ltd., 2017-05-01)
      Implementation of the Oncotype DX assay has led to a change in the manner in which chemotherapy is utilized in patients with early stage, estrogen receptor (ER)-positive, node-negative breast cancer; ensuring that patients ...
    • Coexpression of nos2 and cox2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer 

      Basudhar, Debashree; Glynn, Sharon A.; Greer, Madison; Somasundaram, Veena; No, Jae Hong; Scheiblin, David A.; Garrido, Pablo; Heinz, William F.; Ryan, Aideen E.; Weiss, Jonathan M.; Cheng, Robert Y. S.; Ridnour, Lisa A.; Lockett, Stephen J.; McVicar, Daniel W.; Ambs, Stefan; Wink, David A. (Proceedings of the National Academy of Sciences, 2017-10-27)
      Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have ...
    • The development of a digital intervention to promote timely presentation of breast cancer symptoms to a healthcare professional 

      Carr, Emma (NUI Galway, 2019-10-31)
      Breast cancer is the primary cause of death among women globally and in Ireland, mortality rates from breast cancer are the third highest in Europe. Early diagnosis of breast cancer is linked to more favourable outcomes ...
    • Diagnostic and therapeutic mesenchymal stem cells for breast cancer treatment 

      Dwyer, Róisín M. (Wiley, 2013-08-09)
      [No abstract available]
    • Differential impact of hormone receptor status on survival and recurrence for her2 receptor-positive breast cancers treated with trastuzumab 

      McGuire, Andrew; Kalinina, Olga; Holian, Emma; Curran, Catherine; Malone, Carmel A.; McLaughlin, Ray; Lowery, Aoife; Brown, James A. L.; Kerin, Michael J. (Springer Nature, 2017-04-04)
      Introduction Hormone receptor status has major implications for treatment and survival of breast cancer. Yet the impact of hormone receptor status on outcome after Trastuzumab has received little attention. The objective ...
    • Effects of age on the detection and management of breast cancer 

      McGuire, Andrew; Brown, James; Malone, Carmel; McLaughlin, Ray; Kerin, Michael (MDPI AG, 2015-05-22)
      Currently, breast cancer affects approximately 12% of women worldwide. While the incidence of breast cancer rises with age, a younger age at diagnosis is linked to increased mortality. We discuss age related factors affecting ...
    • Evaluation of variants in the chek2, brip1 and palb2 genes in an irish breast cancer cohort 

      McInerney, N. M.; Miller, N.; Rowan, A.; Colleran, G.; Barclay, E.; Curran, C.; Kerin, M. J.; Tomlinson, I. P.; Sawyer, E. (Springer Nature, 2009-09-18)
      It has been proposed that rare variants within the double strand break repair genes CHEK2, BRIP1 and PALB2 predispose to breast cancer. The aim of this study was to evaluate the prevalence of these variants in an Irish ...
    • Exosome-encapsulated micrornas as circulating biomarkers for breast cancer 

      Joyce, Doireann P.; Kerin, Michael J.; Dwyer, Róisín M. (Wiley-Blackwell, 2016-05-31)
      Breast cancer is a highly prevalent disease, accounting for 29% of invasive cancers in women. Survival from this disease depends on the stage at diagnosis, with patients who are detected earlier having more favourable ...
    • Exploring circulating micro-rna in the neoadjuvant treatment of breast cancer 

      Casey, Máire-Caitlín; Sweeney, Karl J.; Brown, James Andrew Lawrence; Kerin, Michael J. (Wiley-Blackwell, 2016-01-30)
      Breast cancer is the most frequently diagnosed malignancy amongst females worldwide. In recent years the management of this disease has transformed considerably, including the administration of chemotherapy in the neoadjuvant ...
    • Fgf receptor genes and breast cancer susceptibility: results from the breast cancer association consortium 

      Agarwal, D; Pineda, S; Michailidou, K; Herranz, J; Pita, G; Moreno, L T; Alonso, M R; Dennis, J; Wang, Q; Bolla, M K; Meyer, K B; Menéndez-Rodríguez, P; Hardisson, D; Mendiola, M; González-Neira, A; Lindblom, A; Margolin, S; Swerdlow, A; Ashworth, A; Orr, N; Jones, M; Matsuo, K; Ito, H; Iwata, H; Kondo, N; Hartman, M; Hui, M; Lim, W Y; T-C Iau, P; Sawyer, E; Tomlinson, I; Kerin, M; Miller, N; Kang, D; Choi, J-Y; Park, S K; Noh, D-Y; Hopper, J L; Schmidt, D F; Makalic, E; Southey, M C; Teo, S H; Yip, C H; Sivanandan, K; Tay, W-T; Brauch, H; Brüning, T; Hamann, U; Dunning, A M; Shah, M; Andrulis, I L; Knight, J A; Glendon, G; Tchatchou, S; Schmidt, M K; Broeks, A; Rosenberg, E H; van't Veer, L J; Fasching, P A; Renner, S P; Ekici, A B; Beckmann, M W; Shen, C-Y; Hsiung, C-N; Yu, J-C; Hou, M-F; Blot, W; Cai, Q; Wu, A H; Tseng, C-C; Van Den Berg, D; Stram, D O; Cox, A; Brock, I W; Reed, M W R; Muir, K; Lophatananon, A; Stewart-Brown, S; Siriwanarangsan, P; Zheng, W; Deming-Halverson, S; Shrubsole, M J; Long, J; Shu, X-O; Lu, W; Gao, Y-T; Zhang, B; Radice, P; Peterlongo, P; Manoukian, S; Mariette, F; Sangrajrang, S; McKay, J; Couch, F J; Toland, A E; Yannoukakos, D; Fletcher, O; Johnson, N; Silva, I dos Santos; Peto, J; Marme, F; Burwinkel, B; Guénel, P; Truong, T; Sanchez, M; Mulot, C; Bojesen, S E; Nordestgaard, B G; Flyer, H; Brenner, H; Dieffenbach, A K; Arndt, V; Stegmaier, C; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, J M; Lambrechts, D; Yesilyurt, B T; Floris, G; Leunen, K; Chang-Claude, J; Rudolph, A; Seibold, P; Flesch-Janys, D; Wang, X; Olson, J E; Vachon, C; Purrington, K; Giles, G G; Severi, G; Baglietto, L; Haiman, C A; Henderson, B E; Schumacher, F; Le Marchand, L; Simard, J; Dumont, M; Goldberg, M S; Labrèche, F; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Devilee, P; Tollenaar, R A E M; Seynaeve, C; García-Closas, M; Chanock, S J; Lissowska, J; Figueroa, J D; Czene, K; Eriksson, M; Humphreys, K; Darabi, H; Hooning, M J; Kriege, M; Collée, J M; Tilanus-Linthorst, M; Li, J; Jakubowska, A; Lubinski, J; Jaworska-Bieniek, K; Durda, K; Nevanlinna, H; Muranen, T A; Aittomäki, K; Blomqvist, C; Bogdanova, N; Dörk, T; Hall, P; Chenevix-Trench, G; Easton, D F; Pharoah, P D P; Arias-Perez, J I; Zamora, P; Benítez, J; Milne, R L (Springer Nature, 2014-02-18)
      Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor ...
    • Gain of imprinting of slc22a18 sense and antisense transcripts in human breast cancer 

      Gallagher, E.; Mc Goldrick, A.; Chung, W.Y.; Mc Cormack, O.; Harrison, M.; Kerin, M.; Dervan, P.A.; Mc Cann, A. (Elsevier BV, 2006-07-01)
    • Gene expression profiles of no- and hno-donor treated breast cancer cells: insights into tumor response and resistance pathways 

      Cheng, Robert Y.S.; Basudhar, Debashree; Ridnour, Lisa A.; Heinecke, Julie L.; Kesarwala, Aparna H.; Glynn, Sharon; Switzer, Christopher H.; Ambs, Stefan; Miranda, Katrina M.; Wink, David A. (Elsevier BV, 2014-12-01)
      Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates disease progression via NO in a number of pathologies, including cancer. The role of NOS2-derived NO is not only flux-dependent, which is higher ...
    • Growth arrest-specific gene 6 expression in human breast cancer 

      Mc Cormack, O; Chung, W Y; Fitzpatrick, P; Cooke, F; Flynn, B; Harrison, M; Fox, E; Gallagher, E; Goldrick, A Mc; Dervan, P A; Mc Cann, A; Kerin, M J (Springer Nature, 2008-02-19)
      Growth arrest- specific gene 6 ( Gas6), identified in 1995, acts as the ligand to the Axl/ Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/ ...
    • Human endogenous retrovirus k and cancer: innocent bystander or tumorigenic accomplice? 

      Downey, Ronan F.; Sullivan, Francis J.; Wang-Johanning, Feng; Ambs, Stefan; Giles, Francis J.; Glynn, Sharon A. (Wiley-Blackwell, 2014-06-17)
      Harbored as relics of ancient germline infections, human endogenous retroviruses (HERVs) now constitute up to 8% of our genome. A proportion of this sequence has been co-opted for molecular and cellular processes, beneficial ...