Browsing by Subject "Unfolded protein response (UPR)"

Now showing items 1-3 of 3

    • Ex vivo investigation of iron handling in the brain 

      Healy, Sinead (2016-11-04)
      Aberrant iron deposition in the brain is associated with aging and neurodegenerative disorders including multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. It is unclear whether metabolic dyshomeostasis of ...

    • Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling 

      Gorman, Adrienne (Wiley, 2008-06-27)
      Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ...

    • Stress management at the ER: regulators of ER stress-induced apoptosis. 

      Gorman, Adrienne M.; Healy, Sandra J.M.; Jäger, Richard; Samali, Afshin (Elsevier, 2012-02-17)
      The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ...